Les patientes atteintes de thyroïdite d’Hashimoto chronique avaient les niveaux sériques de vitamine D les plus faibles. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract OBJECTIVE: The relation between vitamin D and autoimmune disorders has long been investigated regarding the important roles of this hormone in immune regulation. We evaluated 25-hydroxyvitamin D (25OHD) status in subjects with Hashimoto's thyroiditis (HT) and healthy controls. METHODS: Group-1 included 180 euthyroid patients (123 females/57 males) with HT who were on a stable dose of L-thyroxine (LT). A total of 180 sex-, age-, and body mass index (BMI)-matched euthyroid subjects with newly diagnosed HT were considered as Group-2, and 180 healthy volunteers were enrolled as controls (Group-3). All 540 subjects underwent thyroid ultrasound and were evaluated for serum 25OHD, anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-TG) levels. RESULTS: Group-1 had the lowest 25OHD levels (11.4 ± 5.2 ng/mL) compared to newly diagnosed HT subjects (Group-2) (13.1 ± 5.9 ng/mL, P = .002) and to control subjects (15.4 ± 6.8 ng/mL, P<.001). Serum 25OHD levels directly correlated with thyroid volume (r = 0.145, P<.001) and inversely correlated with anti-TPO (r = -0.361, P<.001) and anti-TG levels (r = -0.335, P<.001). We determined that 48.3% of Group-1, 35% of Group-2, and 20.5% of controls had severe 25OHD deficiency (<10 ng/mL). Female chronic HT patients had the lowest serum 25OHD levels (10.3 ± 4.58 ng/mL), and male control subjects had the highest (19.3 ± 5.9 ng/mL, P<.001). CONCLUSIONS: We demonstrated that serum 25OHD levels of HT patients were significantly lower than controls, and 25OHD deficiency severity correlated with duration of HT, thyroid volume, and antibody levels. These findings may suggest a potential role of 25OHD in development of HT and/or its progression to hypothyroidism. Endocr Pract.2013 May-Jun;19(3):479-84. doi: 10.4158/EP12376.OR.The association between severity of vitamin D deficiency and Hashimoto's thyroiditis. Bozkurt NC1, Karbek B, Ucan B, Sahin M, Cakal E, Ozbek M, Delibasi T. L'ajout d'un antioxydant tel que l'acide ascorbique (la vitamine C), dans la gestion de l'arthrite rhumatoïde peut être d'une grande valeur. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : ABSTRACT Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have distinct contribution to the destructive, proliferative synovitis of rheumatoid arthritis (RA) and play a prominent role in cell-signaling events. However, few studies had clarified the role of individual ROS and RNS in the etiopathogenesis of RA. To date, most of the studies were concerned with the measurement of the total oxidative and nitrative stress levels in RA. The aim of this study was to monitor the levels of individual ROS and RNS to emphasize the role that each plays in the pathogenesis of RA and their usefulness as possible biomarkers for the disease activity. In addition, the effect of an antioxidant (ascorbic acid), added to the treatment regimen, on the levels of ROS, RNS and disease activity has been evaluated. Forty-two Saudi RA patients and 40 healthy controls of both genders were included in this study. Serum levels of six different ROS and three different RNS were measured using specific fluorescent probes. The ROS included the hydroxyl radical ((•)OH), the superoxide anion (O2(•-)), hydrogen peroxide (H2O2), the singlet oxygen ((1)O2), the hypochlorite radical (OHCl(•)), and the peroxyl radical (ROO(•)). The RNS included nitric oxide (NO(•)), nitrogen dioxide (ONO-) and peroxynitrite (ONOO-). The main clinical and biochemical markers for disease activity were assessed and correlated with ROS and RNS levels. The clinical markers included the 28 swollen joint count (SJC-28), the 28-tender joint count (TJC-28), morning stiffness and symmetric arthritis, in addition to the disease activity score assessing 28 joints with erythrocyte sedimentation rate (DAS28-ESR). The biochemical markers included undercarboxylated osteocalcin (ucOC), matrix metalloproteinase (MMP-3), ESR, C-reactive protein (CRP), rheumatoid factor (RF) and anticyclic citrullinated polypeptide (Anti-CCP). Ascorbic acid (1mg/day) was added as an antioxidant to the regular treatment regimen of RA patients for two months, and the levels of ROS and RNS, as well as disease activity were re-evaluated. The results have shown significant higher serum levels of individual ROS and RNS in RA patients compared with healthy subjects. Moreover, this study might be the first to report strong positive correlations between most of the reactive species and the clinical and biochemical markers of RA. Interestingly, the addition of ascorbic acid had significantly reduced the levels of all ROS and RNS in RA patients. In conclusion, the role of oxidative and nitrative stress in the pathogenesis of RA has been confirmed by this study. Serum levels of ROS and RNS may effectively serve as biomarkers for monitoring disease progression. Finally, the addition of an antioxidant, such as ascorbic acid, in the management of RA may be of a great value. RÉFÉRENCE: Free Radic Biol Med. 2016 Aug;97:285-91. doi: 10.1016/j.freeradbiomed.2016.06.020. Epub 2016 Jun 21. Reactive oxygen and nitrogen species in patients with rheumatoid arthritis as potential biomarkers for disease activity and the role of antioxidants. Khojah HM1, Ahmed S2, Abdel-Rahman MS3, Hamza AB4. Les résultats ont démontré une diminution significative de vitamine E dans le sérum des patients atteints de psoriasis, par rapport au groupe témoin. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : ABSTRACT - BACKGROUND: Psoriasis is a common skin disease which is characterized by increased epidermal proliferation and dermal inflammation affecting 0.1-3% of general population. Most of the psoriasis patients are young or middle aged adults, although no age exempted. The oxidative stress develops due to imbalance in oxidants and antioxidants, which was proposed to have role in psoriasis. AIMS AND OBJECTIVES: The presented research work was planned to evaluate oxidative stress by measuring serum malondialdehyde (MDA) as oxidant and serum vitamin E, erythrocyte catalase (CAT) activity as antioxidants in psoriasis patients. MATERIALS AND METHODS: Total 90 clinically diagnosed psoriasis patients of age group of 20 to 60 years and without any drug therapy for preceding two months and 90 matched healthy controls were included in the presented study. The severity of psoriasis was determined by PASI score. The fasting blood sample collected and accessed for serum MDA, serum vitamin E and erythrocyte catalase activity. RESULTS: The study results were compiled and statistical analysis was done using students t-test. Our results showed significantly increased levels of serum MDA (p<0.001) and significantly decreased serum vitamin E (p<0.001) as well as erythrocyte catalase activity (p<0.001) in psoriasis patients as compared to controls. CONCLUSION: The presented study concluded the oxidative stress in psoriasis, indicated by increased serum MDA and decreased Vitamin E, erythrocyte catalase activity. Our study also supports the possibility of involvement of oxidative stress in pathogenesis of psoriasis. RÉFÉRENCE: J Clin Diagn Res. 2014 Nov;8(11):CC14-6. doi: 10.7860/JCDR/2014/10912.5085. Epub 2014 Nov 20. The serum levels of malondialdehyde, vitamin e and erythrocyte catalase activity in psoriasis patients. Pujari VM1, Ireddy S2, Itagi I3, Kumar H S4. La vitamine A améliore le score composite fonctionnel total de la sclérose en plaques chez les patients atteints de sclérose en plaques rémittente-récurrente. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : ABSTRACT - BACKGROUND: Many studies have shown that active vitamin A derivatives suppress the formation of pathogenic T cells in multiple sclerosis (MS) patients. The aim of the present study is to determine the impact of vitamin A on disease progression in MS patients. METHODS: A total of 101 relapsing-remitting MS (RRMS) patients were enrolled in a 1-year placebo-controlled randomized clinical trial. The treated group received 25000 IU/d retinyl palmitate for six month followed by 10000 IU/d retinyl palmitate for another six month. The results of the expanded disability status scale (EDSS) and multiple sclerosis functional composite (MSFC) were recorded at the beginning and the end of the study. The relapse rate was recorded during the intervention. Patients underwent baseline and follow up brain MRIs. RESULTS: The results showed "Mean ± SD" of MSFC changes in the treated group was (-0.14 ± 0.20) and in the placebo group was (-0.31 ± 0.19). MSFC was improved significantly (P < 0.001) in the treatment group. There were no significant differences between the "Mean ± SD" of EDSS changes in the treated (0.07 ± 0.23) and placebo (0.08 ± 0.23) groups (P = 0.73). There were also no significant differences between the "Mean ± SD" of annualized relapse rate in the treated group (-0.36 ± 0.56) and placebo (-0.53 ± 0.55) groups (P = 0.20). The "Mean ± SD" of enhanced lesions in the treatment (0.4 ± 1.0) and in the placebo (0.2 ± 0.6) groups were not significantly different (P = 0.26). Volume of T2 hyperintense lesions "Mean ± SD" was not significantly different between treatment (45 ± 137) and placebo (23 ± 112) groups after intervention (P = 0.23). CONCLUSION: Vitamin A improved total MSFC score in RRMS patients, but it did not change EDSS, relapse rate and brain active lesions. Arch Iran Med. 2015 Jul;18(7):435-40. doi: 0151807/AIM.008. Impact of Vitamin A Supplementation on Disease Progression in Patients with Multiple Sclerosis. Bitarafan S1, Saboor-Yaraghi A2, Sahraian MA3, Nafissi S4, Togha M5, Beladi Moghadam N6, Roostaei T3, Siassi F7, Eshraghian MR8, Ghanaati H9,Jafarirad S10, Rafiei B9, Harirchian MH11. Une baisse significative des niveaux d'antioxydants a été observée dans la polyarthrite rhumatoïde. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract - BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Highly reactive oxygen free radicals are believed to be involved in the pathogenesis of the disease. In this study, RA patients were sub-grouped depending upon the presence or absence of rheumatoid factor, disease activity score and disease duration. RA Patients (120) and healthy controls (53) were evaluated for the oxidant-antioxidant status by monitoring ROS production, biomarkers of lipid peroxidation, protein oxidation and DNA damage. The level of various enzymatic and non-enzymatic antioxidants was also monitored. Correlation analysis was also performed for analysing the association between ROS and various other parameters. METHODS: Intracellular ROS formation, lipid peroxidation (MDA level), protein oxidation (carbonyl level and thiol level) and DNA damage were detected in the blood of RA patients. Antioxidant status was evaluated by FRAP assay, DPPH reduction assay and enzymatic (SOD, catalase, GST, GR) and non-enzymatic (vitamin C and GSH) antioxidants. RESULTS: RA patients showed a higher ROS production, increased lipid peroxidation, protein oxidation and DNA damage. A significant decline in the ferric reducing ability, DPPH radical quenching ability and the levels of antioxidants has also been observed. Significant correlation has been found between ROS and various other parameters studied. CONCLUSION: RA patients showed a marked increase in ROS formation, lipid peroxidation, protein oxidation, DNA damage and decrease in the activity of antioxidant defence system leading to oxidative stress which may contribute to tissue damage and hence to the chronicity of the disease. RÉFÉRENCE: PLoS One. 2016 Apr 4;11(4):e0152925. doi: 10.1371/journal.pone.0152925. eCollection 2016. Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis. Mateen S1, Moin S1, Khan AQ2, Zafar A3, Fatima N1. L’état nutritionnel faible en sélénium est associé à un risque accru de maladie de la thyroïde. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : ABSTRACT OBJECTIVES: Epidemiological studies have supported the premise that an adequate selenium intake is essential for thyroid gland function. OBJECTIVE: The objective was to investigate whether the prevalence of thyroid disease differed in two areas that were similar, except for very different soil/crop selenium concentrations. DESIGN: Cross-sectional observational study. SETTING: The setting was two counties of Shaanxi Province, China, here defined as adequate- and low-selenium. PARTICIPANTS: A total of 6152 participants were selected by stratified cluster-sampling. MAIN OUTCOME MEASURES: Participants completed demographic and dietary questionnaires and underwent physical and thyroid ultrasound examinations. Serum samples were analyzed for thyroid function parameters and selenium concentration. Serum selenium was compared between different demographic, dietary, and lifestyle categories in the two counties. The relationship between selenium status, dietary factors, and pathological thyroid conditions was explored by logistic regression. RESULTS: Complete data sets were available from 3038 adequate-selenium participants and 3114 low-selenium participants in whom median (interquartile range) selenium concentrations differed almost 2-fold (103.6 [79.7, 135.9] vs 57.4 [39.4, 82.1] μg/L; P = .001). The prevalence of pathological thyroid conditions (hypothyroidism, subclinical hypothyroidism, autoimmune thyroiditis, and enlarged thyroid) was significantly lower in the adequate-selenium county than in the low-selenium county (18.0 vs 30.5%; P < .001). Higher serum selenium was associated with lower odds ratio (95% confidence interval) of autoimmune thyroiditis (0.47; 0.35, 0.65), subclinical hypothyroidism (0.68; 0.58, 0.93), hypothyroidism (0.75; 0.63, 0.90), and enlarged thyroid (0.75; 0.59, 0.97). CONCLUSIONS: Low selenium status is associated with increased risk of thyroid disease. Increased selenium intake may reduce the risk in areas of low selenium intake that exist not only in China but also in many other parts of the world. RÉFÉRENCE: J Clin Endocrinol Metab. 2015 Nov;100(11):4037-47. doi: 10.1210/jc.2015-2222. Epub 2015 Aug 25. Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease. Wu Q1, Rayman MP1, Lv H1, Schomburg L1, Cui B1, Gao C1, Chen P1, Zhuang G1, Zhang Z1, Peng X1, Li H1, Zhao Y1, He X1, Zeng G1, Qin F1, Hou P1, Shi B1. Une proportion importante de la population souffrant du syndrome du côlon irritable était carencée en vitamine D. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : ABSTRACT OBJECTIVES: Vitamin D has been found to be strongly associated with many systemic disorders. There has been an augmented interest within the medical community in vitamin D, especially its deficiency, in various systemic disorders. Although the role of vitamin D deficiency in irritable bowel syndrome (IBS) has not yet been established, studies are underway to clearly establish its role in the disease. The objective of our study was to elucidate and establish the role of vitamin D deficiency in IBS patients compared to a healthy control group. METHODS: This study is a comparative case control study of vitamin D deficiency in patients with IBS diagnosed with ROME 3 criteria of classification (the third ROME foundation classification) to an age and gender matched healthy control group. The vitamin D level was measured in both cohorts for comparison and the results interpreted statistically. Sixty patients with IBS and 100 healthy individuals were included as test and control groups, respectively, in the study. The mean serum vitamin D level (nmol/L) of IBS patients was compared to the control group. RESULTS: Vitamin D deficiency was detected in 49 patients (82%) in the IBS group and 31 patients (31%) in the control group. There was a statistically significant difference in the mean vitamin D level (p=0.025) between the IBS group and control group. CONCLUSIONS: Our study shows that vitamin D deficiency is highly prevalent in patients with IBS and these results seem to have therapeutic implications. Vitamin D supplementation could play a therapeutic role in the control of IBS. Oman Med J. 2015 Mar;30(2):115-8. doi: 10.5001/omj.2015.25. Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist? Khayyat Y1, Attar S2. La thyroïdite de Hashimoto est une inflammation chronique du tissu thyroïdien dans lequel votre système immunitaire attaque la glande thyroïde. Ceci est une maladie auto-immune et conduit souvent à l'hypothyroïdie.
L'hypothyroïdie peut être due à un certain nombre de facteurs tels que : facteurs congénitales, maladies inflammatoires chroniques (maladies auto-immunes), traitement de l'hyperthyroïdie, de l’ablation de la thyroïde (chirurgie de la thyroïde), la radiothérapie autour du cou, la grossesse, l'alimentation végétarienne, les médicaments (comme le lithium) ainsi qu’a des déficiences nutritionnelles. Les micronutriments sont nécessaires pour renforcer le système de défenses antioxydantes déficient et pour la synthèse et la fonction de l'hormone thyroïdienne. Les niveaux moyens de vitamine E (alpha-tocophérol) étaient plus faibles chez les personnes atteintes de dégénérescence maculaire exsudative.
RÉFÉRENCE: Veuillez lire l'article complet (en anglais seulement) : Abstract OBJECTIVE: To investigate relationships between levels of tocopherols and carotenoids in the serum and age-related macular degeneration (ARMD). DESIGN: A nested case-control study within a population-based cohort. PARTICIPANTS: Cases included a sample of subjects with retinal pigment abnormalities with the presence of soft drusen (n = 127) or with late ARMD (geographic atrophy [n = 9]) or neovascular and exudative macular degeneration (n = 31). An equal number of controls (167 pairs) were selected from among participants in the Beaver Dam Eye Study. The controls had no photographic evidence of soft drusen, retinal pigment abnormalities, or late ARMD and were matched with cases for age, sex, and current smoking status. DATA COLLECTION: Presence and severity of ARMD were determined from masked grading of fundus photographs obtained from 1988 to 1990. Levels of individual carotenoids and tocopherols were determined in serum collected at the same time. RESULTS: Average levels of individual carotenoids were similar in cases and controls. Average levels of vitamin E (alpha-tocopherol) were lower in people with exudative macular degeneration (P = .03). However, the difference was no longer statistically significant after controlling for levels of cholesterol in the serum. Persons with levels of lycopene, the most abundant carotenoid in the serum, in the lowest quintile were twice as likely to have ARMD. Levels of the carotenoids that compose macular pigment (lutein with zeaxanthin) in the serum were unrelated to ARMD. CONCLUSIONS: Very low levels of one (lycopene) but not other dietary carotenoids or tocopherols were related to ARMD. Lower levels of vitamin E in subjects with exudative macular degeneration compared with controls may be explained by lower levels of serum lipids. Arch Ophthalmol. 1995 Dec;113(12):1518-23. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Mares-Perlman JA1, Brady WE, Klein R, Klein BE, Bowen P, Stacewicz-Sapuntzakis M, Palta M. https://www.ncbi.nlm.nih.gov/pubmed/7487619 De faibles niveaux de vitamine D sont associés à la nouvelle apparition de douleurs chroniques généralisées - il y eu une association positive brute entre l’hypovitaminose D et la douleur chronique généralisée. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : ABSTRACT BACKGROUND: Chronic widespread pain (CWP) is a global musculoskeletal disorder leading to disability and a reduced quality of life. Low levels of serum vitamin D has long been proposed to be associated with CWP, but previous research remains inconclusive. OBJECTIVES: To determine whether hypovitaminosis D was independently associated with CWP. STUDY DESIGN: Meta-analysis of observational study. METHODS: Electronic databases were searched for studies published up to November 2014 comparing the prevalence of hypovitaminosis D and serum vitamin D levels between participants with and without CWP. The crude and adjusted odds ratios (ORs) of hypovitaminosis D with CWP were calculated. Subgroup analysis according to gender, threshold of hypovitaminosis, and definition of patients was performed, as well as meta-regression to test the linear relationship between crude ORs and the latitude of study locations. RESULTS: Twelve studies were included, comprising 1,854 patients with CWP. The patient group showed a significantly higher risk of hypovitaminosis D than the control group (crude OR, 1.63; 95% CI, 1.20-2.23). The association was slightly attenuated after adjusting confounders, with a pooled adjusted OR of 1.41 (95% CI, 1.00-2.00). There was an increase in ORs of hypovitaminosis D using a lower diagnostic value of serum vitamin D (8 and 10 ng/mL). The subgroup analysis according to gender and definition of CWP did not reveal significant between-group differences. The meta-regression showed no linear relationship between latitude and the crude ORs. CONCLUSIONS: There was a positive crude association between hypovitaminosis D and CWP, and the association was likely to remain after adjusting confounding factors. Use of a cut-off value of hypovitaminosis D (8-10 ng/mL) could better define the population with and without CWP. Further prospective follow-up studies are warranted to clarify the causal relationship between hypovitaminosis D and CWP. Pain Physician. 2015 Sep-Oct;18(5):E877-87. Is Serum Hypovitaminosis D Associated with Chronic Widespread Pain Including Fibromyalgia? A Meta-analysis of Observational Studies. Hsiao MY1, Hung CY2, Chang KV1, Han DS1, Wang TG3. https://www.ncbi.nlm.nih.gov/pubmed/26431141 De nombreuses maladies neurodégénératives, diabète, cancer, fibromyalgie, maladies cardio-vasculaires et musculaires ont été associés à de bas niveaux de CoQ10.
RÉFÉRENCE: Veuillez lire l'article complet (en anglais seulement) : ABSTRACT Coenzyme Q10 (CoQ10) or ubiquinone was known for its key role in mitochondrial bioenergetics as electron and proton carrier; later studies demonstrated its presence in other cellular membranes and in blood plasma, and extensively investigated its antioxidant role. These two functions constitute the basis for supporting the clinical indication of CoQ10. Furthermore, recent data indicate that CoQ10 affects expression of genes involved in human cell signalling, metabolism and transport and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, ageing-related oxidative stress and carcinogenesis processes, and also a secondary effect of statin treatment. Many neurodegenerative disorders, diabetes, cancer, fibromyalgia, muscular and cardiovascular diseases have been associated with low CoQ10 levels. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral CoQ10 treatment is a frequent mitochondrial energizer and antioxidant strategy in many diseases that may provide a significant symptomatic benefit. RÉFÉRENCE: Front Biosci (Landmark Ed). 2014 Jan 1;19:619-33. Clinical applications of coenzyme Q10. Garrido-Maraver J1, Cordero MD2, Oropesa-Avila M1, Vega AF1, de la Mata M1, Pavon AD1, Alcocer-Gomez E1, Calero CP1, Paz MV1, Alanis M1, de Lavera I1, Cotan D1, Sanchez-Alcazar JA1. https://www.ncbi.nlm.nih.gov/pubmed/24389208 Dans les études concernant les patients dépressifs, on a identifié de bas niveaux de folate et de vitamine B12. De plus, une association entre la dépression et le faible niveau de ces deux vitamines fût constatée dans les études concernant la population générale. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : ABSTRACT We review the findings in major depression of a low plasma and particularly red cell folate, but also of low vitamin B12 status. Both low folate and low vitamin B12 status have been found in studies of depressive patients, and an association between depression and low levels of the two vitamins is found in studies of the general population. Low plasma or serum folate has also been found in patients with recurrent mood disorders treated by lithium. A link between depression and low folate has similarly been found in patients with alcoholism. It is interesting to note that Hong Kong and Taiwan populations with traditional Chinese diets (rich in folate), including patients with major depression, have high serum folate concentrations. However, these countries have very low life time rates of major depression. Low folate levels are furthermore linked to a poor response to antidepressants, and treatment with folic acid is shown to improve response to antidepressants. A recent study also suggests that high vitamin B12 status may be associated with better treatment outcome. Folate and vitamin B12 are major determinants of one-carbon metabolism, in which S-adenosylmethionine (SAM) is formed. SAM donates methyl groups that are crucial for neurological function. Increased plasma homocysteine is a functional marker of both folate and vitamin B12 deficiency. Increased homocysteine levels are found in depressive patients. In a large population study from Norway increased plasma homocysteine was associated with increased risk of depression but not anxiety. There is now substantial evidence of a common decrease in serum/red blood cell folate, serum vitamin B12 and an increase in plasma homocysteine in depression. Furthermore, the MTHFR C677T polymorphism that impairs the homocysteine metabolism is shown to be overrepresented among depressive patients, which strengthens the association. On the basis of current data, we suggest that oral doses of both folic acid (800 microg daily) and vitamin B12 (1 mg daily) should be tried to improve treatment outcome in depression. J Psychopharmacol. 2005 Jan;19(1):59-65. Treatment of depression: time to consider folic acid and vitamin B12. Coppen A1, Bolander-Gouaille C. www.ncbi.nlm.nih.gov/pubmed/15671130 Une corrélation fût démontrée entre l'intensité de la déficience en coenzyme Q10 et un mauvais pronostic de la maladie du sein. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract BACKGROUND: Coenzyme Q10 or ubiquinone is a redox component of the respiratory chain, which may be involved in the pathogenesis of cancer. METHODS: In order to better understand the role of this vitamin in the pathogenesis of breast cancer, a clinical trial including 200 women hospitalized for the biopsy and/or the ablation of a breast tumor was conducted. Ubiquinone plasma concentrations were determined simultaneously with vitamin E plasma concentrations (as antioxidant reference) by HPLC. RESULTS: A coenzyme Q10 deficiency was noted both in carcinomas (80 patients) and non-malignant lesions (120 patients), while vitamin E concentrations were within the normal range. A correlation was shown between the intensity of the deficiency and the bad prognosis of the breast disease based on high TNM and SBR values or the lack of estrogen receptors. However, neither cathepsin D level nor adenopathy invasion was related to ubiquinone levels. CONCLUSIONS: Since prooxidants may promote tumorigenesis, ubiquinone supplementation in breast cancer could be relevant. Int J Clin Pharmacol Ther. 1998 Sep;36(9):506-9. Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences. Jolliet P1, Simon N, Barré J, Pons JY, Boukef M, Paniel BJ, Tillement JP. http://www.ncbi.nlm.nih.gov/pubmed/9760013 Des faibles niveaux de vitamine D semblent affecter négativement l'épaisseur du cartilage du fémur. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract This study aims to investigate the association between vitamin D levels and distal femoral cartilage thickness in healthy subjects. Eighty patients who were admitted to our outpatient clinic between May and July 2013 were classified into three subgroups according to their 25-OH vitamin D levels of <10, 10-20, and ≥20 ng/mL. Distal femoral cartilage thickness was measured from the midpoints of the right medial condyle (RMC), right lateral condyle (RLC), right intercondylar area (RIA), left medial condyle (LMC), left lateral condyle (LLC), and left intercondylar area (LIA) by using musculoskeletal ultrasound (US). The group with severe vitamin D deficiency (<10 ng/mL) had thinner femoral cartilage thickness at LMC (p = 0.005). Positive correlations were determined only between vitamin D levels and US measurements in the severe vitamin D deficiency group at RLC (r = 444, p = 0.020), LMC (r = 357, p = 0.067), and LLC (r = 568, p = 0.002). Low levels of vitamin D seem to affect the femoral cartilage thickness, adversely. Further studies are necessary to ascertain the clinical relevance of this change in cartilage thickness and whether vitamin D supplementation can reverse the cartilage thinning process or the allied clinical symptoms in the course of knee osteoarthritis. Clin Rheumatol. 2014 Sep;33(9):1331-4. doi: 10.1007/s10067-013-2432-y. Epub 2013 Nov 13. Does vitamin D affect femoral cartilage thickness? An ultrasonographic study. Malas FU1, Kara M, Aktekin L, Ersöz M, Ozçakar L. http://www.ncbi.nlm.nih.gov/pubmed/24221506 La vitamine D influence l'activité et la sévérité de la polyarthrite rhumatoïde. Voici les résultats de cette étude:
RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Dis Markers. 2015;2015:260725. doi: 10.1155/2015/260725. Epub 2015 May 10. Vitamin D Is a Good Marker for Disease Activity of Rheumatoid Arthritis Disease. Azzeh FS1, Kensara OA1. Author information Abstract AIM:This study was conducted to find out the optimal vitamin D cutoff point in predicting activity of RA disease. MATERIALS AND METHODS: One hundred and two rheumatoid arthritis Saudi patients of both genders were recruited in this study. Vitamin D as 25-hydroxy-vitamin D [25(OH)D] was measured and serum level less than 20 ng/mL defined as deficient patient. Disease activity was measured based on the disease activity score index of a 28-joint count (DAS28) using serum erythrocyte sedimentation rate levels. Receiver operating characteristic (ROC) curves were used to determine the optimal vitamin D cutoff points for identifying disease activity. RESULTS: It has been observed that vitamin D levels were lower (P < 0.05) in patients with high disease activity. A significant inverse correlation between serum 25(OH)D levels and DAS28 (r = -0.277, P = 0.014) was shown. ROC curves results showed that vitamin D less than 12.3 ng/mL predicted high disease activity, and vitamin D more than 17.9 ng/mL predicted low disease activity, with good sensitivity and accuracy results regarding vitamin D. CONCLUSION:Study results concluded that vitamin D is a good predictor of RA disease activity in Saudi patients. PUBMED link: http://www.ncbi.nlm.nih.gov/pubmed/26063950 La polyarthrite rhumatoïde est une maladie auto-immune inflammatoire chronique qui touche préférentiellement les articulations (en particulier les articulations des mains, les poignets, les pieds, les genoux, cubitus, chevilles, épaules, etc.). Les symptômes peuvent être douleur, chaleur, gonflement des articulations, raideur, impotence fonctionnelle etc.
Une série de publications traitant de l'activité anti-inflammatoire de différents extraits alimentaires (comme les nutraceutiques) pourrait être utile comme médecine complémentaire pour la gestion de l'arthrite rhumatoïde. Il y a de plus en plus de preuves scientifiques concernant l'utilisation de compléments alimentaires comme adjuvants dans le traitement de cette maladie. La supplémentation en vitamine E est associée à une résistance accrue à plusieurs agents pathogènes, en particulier chez les personnes âgées, qui sont plus à risque d’avoir un apport alimentaire insuffisant en vitamine E. Référence:
Vitamin E supplementation in old mice induces antimicrobial activity and improves the efficacy of daptomycin in an animal model of wounds infected with methicillin-resistant Staphylococcus aureus Elisa Pierpaoli1, Oscar Cirioni2, Alessandra Barucca1, Fiorenza Orlando1, Carmela Silvestri2, Andrea Giacometti2 and Mauro Provinciali1,* http://jac.oxfordjournals.org/content/66/9/2184.full Le syndrome de l'intestin irritable: de faibles apports en vitamine A, D, calcium, magnésium et zinc ont été détectés. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract OBJECTIVES: The aim of our study was to evaluate the oral dietary intake of a group of patients with irritable bowel syndrome and to compare with international recommendations. PATIENTS AND METHODS: A total of 53 patients with irritable bowel syndrome was enrolled in a non-propabilistic sample. Patients were diagnose with Roma II criteria. In all patients were determined, weight, height, body mass index, dietary intake of 3 days and a symptoms scoring system. RESULTS: The average age of 53 patients was 45.67+/-13.6 years with a distribution of sex (22 males/31 females). Caloric intakes was right in absolute terms and corrected by weight. Distribution of calories was 41.5% of carbohydrates, a 19.8% of proteins, and a 38.7% of lipids, showing a high intake of lipids and low of carbohydrates. A low intake of vitamin A and D was detected. High intake of vitamin B12, vitamin C and niacine was observed. A low intake of calcium, magnesium, yodo and zinc was detected. Intake of soluble fiber was lower than insoluble fiber (1.46+/-0.74 g/day) (19%) vs 6.21+/-2.67 g/day (71%). Intake of fiber corrected by calories was low 4.5+/-1.2 g/1000 calories. In correlation analysis, insoluble fiber (r=0.46; p < 0.05) and soluble fiber (r=0.42; p < 0.05) were inverse correlated with general symptoms. CONCLUSIONS: Patients with irritable bowel syndrome showed a deviation of mineral and vitamin dietary. Fiber intake is low, a correlation between fiber intake and general symptoms was detected. An Med Interna. 2004 Dec;21(12):577-80. Dietary intake of a group of patients with irritable bowel syndrome; relation between dietary fiber and symptoms. Aller R1, de Luis DA, Izaola O, La Calle F, del Olmo L, Fernández L, Arranz T, González Hernández JM. Les concentrations de CoQ10 furent diminuées de manière significative à la fois dans le plasma et le sang total des asthmatiques. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract BACKGROUND: The contribution of free oxygen radicals in the pathogenesis of bronchial asthma is generally accepted. The modulation of antioxidative defence by supplementation with antioxidants represents additive therapy in complex management of disease. The aim of the study was to assess the levels of coenzyme Q10, alpha-tocopherol, and beta-carotene both in plasma and whole blood, and malondialdehyde (MDA) and eosinophil cationic protein (ECP) in plasma of asthmatics (As). METHODS: Fifty-six As (15 males and 41 females) aged from 19 to 72 years (mean age 46 years) suffering from allergic asthma were enrolled into the study. The control group comprised 25 healthy volunteers (16 males, 9 females) aged 25-50 years. RESULTS: The concentrations of CoQ10 decreased significantly both in plasma and whole blood, compared with healthy volunteers (0.34 +/- 0.15 micromol/l vs. 0.52 +/- 0.15 micromol/l, 0.33 +/- 0.14 micromol/l vs. 0.50 +/- 0.13 micromol/l, P < 0.001, P< 0.001, respectively). The levels of alpha-tocopherol were decreased both in plasma and whole blood in comparison with controls [24.10 micromol/l (19.8; 30.5), vs. 33.20 micromol/l (28.25; 38.05), 17.22 +/- 6.45 micromol/l vs. 21.58 +/- 7.92 micromol/l, P= 0.006, P = 0.01, respectively]. The levels of MDA were elevated over the reference range in both groups (reference range < 4.5 micromol/l). No changes were seen in beta-carotene concentrations. Positive correlation was found between whole blood CoQ10 and alpha-tocopherol concentrations. CONCLUSION: Results of the study suggest a possible contribution of suboptimal concentrations of CoQ10 on antioxidative dysbalance in As and provide a rationale for its supplementation. Allergy. 2002 Sep;57(9):811-4. Decreased levels of coenzyme Q(10) in patients with bronchial asthma. Gazdík F1, Gvozdjáková A, Nádvorníková R, Repická L, Jahnová E, Kucharská J, Piják MR, Gazdíková K. Les niveaux de vitamine A et E étaient significativement plus faibles chez les sujets diabétiques de type II. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract Plasma vitamin A, C and E levels and erythrocyte antioxidant enzyme activities were investigated in type I and type II diabetic subjects with and without complications, i.e., hypertension, coronary artery disease and renal failure. Reverse phase HPLC was used to quantify vitamin A and E levels. We observed that the vitamin C levels were not significantly different between control and diabetic subjects. However, vitamin A and E levels were significantly lower in type I and type II diabetic subjects compared to controls. Superoxide dismutase (SOD) activity was significantly lower in type II, but not in type I, diabetic patients compared to controls. Interestingly, glutathione reductase and peroxidase activities were diminished in type I, but not in type II, diabetic subjects as compared to controls. Catalase activity was lower in both types of diabetic patients in comparison with their respective controls. Altogether these results suggest that diabetes mellitus may be associated with altered antioxidant status regardless to various complications. Gen Physiol Biophys. 2003 Mar;22(1):15-27. Antioxidant status and levels of different vitamins determined by high performance liquid chromatography in diabetic subjects with multiple complications. Merzouk S1, Hichami A, Madani S, Merzouk H, Berrouiguet AY, Prost J, Moutairou K, Chabane-Sari N, Khan NA. Les carences nutritionnelles spécifiques chez les patients présentant la maladie d'Alzheimer comprennent les acides gras oméga-3, plusieurs vitamines B et les antioxydants tels que les vitamines E et C. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract Epidemiological evidence linking nutrition to the incidence and risk of Alzheimer Disease is rapidly increasing. The specific nutritional deficiencies in Alzheimer patients may suggest a relative shortage of specific macro- and micronutrients. These include omega-3 fatty acids, several B-vitamins and antioxidants such as vitamins E and C. Recent mechanistic studies in cell systems and animal models also support the idea that nutritional components are able to counteract specific aspects of the neurodegenerative and pathological processes in the brain. In addition, it has been shown that several nutritional components can also effectively stimulate membrane formation and synapse formation as well as improve behavior and cerebrovascular health.The suggested synergy between nutritional components to improve neuronal plasticity and function is supported by epidemiological studies as well as experimental studies in animal models. The ability of nutritional compositions to stimulate synapse formation and effectively reduce Alzheimer Disease neuropathology in these preclinical models provides a solid basis to predict potential to modify the disease process, especially during the early phases of Alzheimer Disease. Eur J Pharmacol. 2008 May 6;585(1):197-207. doi: 10.1016/j.ejphar.2008.01.049. Epub 2008 Mar 4. The potential role of nutritional components in the management of Alzheimer's Disease. van der Beek EM1, Kamphuis PJ. Des études cliniques ont démontré l'efficacité de la supplémentation du calcium, cuivre, manganèse et zinc pour la densité minérale osseuse de la colonne vertébrale chez la femme ménopausée. Chacune de ces études ont démontré l’importance des oligo-éléments pour le développement optimal de la matrice osseuse et du maintien de la densité osseuse. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract Osteoporosis is a multifactorial disease with dimensions of genetics, endocrine function, exercise and nutritional considerations. Of particular considerations are calcium (Ca) status, Vitamin D, fluoride, magnesium and other trace elements. Several trace elements, particularly copper (Cu), manganese (Mn) and zinc (Zn), are essential in bone metabolism as cofactors for specific enzymes. Our investigations regarding the role of Cu, Mn and Zn in bone metabolism include data from studies with animals on Cu- and Mn-deficient diets. We have also demonstrated cellular deficiencies using bone powder implants, as well as fundamental changes in organic matrix constituents. In clinical studies we have demonstrated the efficacy of Ca, Cu, Mn and Zn supplementation on spinal bone mineral density in postmenopausal women. Each of these studies demonstrated the necessity of trace elements for optimal bone matrix development and bone density sustenance. J Am Coll Nutr. 1993 Aug;12(4):384-9. The role of trace minerals in osteoporosis. Saltman PD1, Strause LG. Les patients atteints du syndrome fibromyalgique sécrètent moins de mélatonine pendant les heures d'obscurité que les sujets sains. Cela pourrait contribuer à altérer le sommeil durant la nuit, à causer de la fatigue pendant la journée et à modifier la perception de la douleur. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract Fibromyalgia syndrome (FMS) is a complex chronic condition causing widespread pain and variety of other symptoms. It produces pain in the soft tissues located around joints throughout the body. FMS has unknown etiology and its pathophysiology is not fully understood. However, abnormality in circadian rhythm of hormonal profiles and cytokines has been observed in this disorder. Moreover, there are reports of deficiency of serotonin, melatonin, cortisol and cytokines in FMS patients, which are fully regulated by circadian rhythm. Melatonin, the primary hormone of the pineal gland regulates the body's circadian rhythm and normally its levels begin to rise in the mid-to-late evening, remain high for most of the night, and then decrease in the early morning. FMS patients have lower melatonin secretion during the hours of darkness than the healthy subjects. This may contribute to impaired sleep at night, fatigue during the day and changed pain perception. Studies have shown blunting of normal diurnal cortisol rhythm, with elevated evening serum cortisol level in patients with FMS. Thus, due to perturbed level of cortisol secretion several symptoms of FMS may occur. Moreover, disturbed cytokine levels have also been reported in FMS patients. Therefore, circadian rhythm can be an important factor in the pathophysiology, diagnosis and treatment of FMS. This article explores the circadian pattern of abnormalities in FMS patients, as this may help in better understanding the role of variation in symptoms of FMS and its possible relationship with circadian variations of melatonin, cortisol, cytokines and serotonin levels. Indian J Biochem Biophys. 2011 Apr;48(2):82-7. Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome. Mahdi AA1, Fatima G, Das SK, Verma NS. Les apports alimentaires en acide folique et en vitamine B6 ont été inversement associés à la mortalité par insuffisance cardiaque chez les hommes et à la mortalité par accident vasculaire cérébral, par maladie coronarienne et par maladie cardiovasculaire totale chez les femmes. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract BACKGROUND AND PURPOSE: The association of dietary folate and B vitamin intakes with risk of cardiovascular disease is controversial, and the evidence in Asian populations is limited. METHODS: A total of 23 119 men and 35 611 women, age 40 to 79 years, completed a food frequency questionnaire in the Japan Collaborative Cohort Study. During the median 14-year follow-up, there were 986 deaths from stroke, 424 from coronary heart disease, and 2087 from cardiovascular disease. RESULTS: Dietary folate and vitamin B(6) intakes were inversely associated with mortality from heart failure for men and with mortality from stroke, coronary heart disease, and total cardiovascular disease for women. These inverse associations did not change materially after adjustment for cardiovascular risk factors. No association was found between vitamin B(12) intake and mortality risk. CONCLUSIONS: High dietary intakes of folate and vitamin B(6) were associated with reduced risk of mortality from stroke, coronary heart disease, and heart failure among Japanese. Stroke. 2010 Jun;41(6):1285-9. doi: 10.1161/STROKEAHA.110.578906. Epub 2010 Apr 15. Dietary folate and vitamin b6 and B12 intake in relation to mortality from cardiovascular diseases: Japan collaborative cohort study. Cui R1, Iso H, Date C, Kikuchi S, Tamakoshi A; Japan Collaborative Cohort Study Group. Les résultats suggèrent que de faibles niveaux tissulaires d'acides gras oméga-3, seraient un facteur de risque de tentative suicidaire. RÉFÉRENCE:
Veuillez lire l'article complet (en anglais seulement) : Abstract BACKGROUND: Epidemiologic studies show that low fish intake is a risk factor of suicidality; however, there are no case-control studies investigating suicide attempt risk and tissue n-3 fatty acid levels. METHODS: We recruited 100 suicide-attempt cases and another 100 control patients injured by accidents who were admitted to three hospitals affiliated with Dalian Medical University in Dalian, China. Case and control subjects were matched for age, gender, and smoking status. Those who were inebriated at the time of hospitalization were excluded. Blood was sampled immediately after admission to a hospital. Washed red blood cells (RBCs) were obtained, and the fatty acid composition of the total RBC phospholipid fraction was analyzed by gas chromatography. RESULTS: Eicosapentaenoic acid (EPA) levels in RBC in the case subjects were significantly lower than those of the control subjects (.74 +/-.52% vs. 1.06 +/-.62%, p <.0001). When the highest and lowest quartiles of EPA in RBC were compared, the odds ratios of suicide attempt was.12 in the highest quartile (95% confidence interval:.04-.36, p for trend =.0001) after adjustment for possible confounding factors. CONCLUSIONS: Our findings suggest that low n-3 fatty acid levels in tissues were a risk factor of suicide attempt. Further studies including intervention with fish oil are warranted. http://www.ncbi.nlm.nih.gov/pubmed/15450784 Biol Psychiatry. 2004 Oct 1;56(7):490-6. Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Huan M1, Hamazaki K, Sun Y, Itomura M, Liu H, Kang W, Watanabe S, Terasawa K, Hamazaki T. |
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