Le lien entre la vitamine D et la polyarthrite rhumatoïde

La vitamine D influence l'activité et la sévérité de la  polyarthrite rhumatoïde. 
​Voici les résultats de cette étude: 

• On a observé de plus faibles niveaux de vitamine D chez les patients ayant une activité élevée de la maladie.
• Des niveaux de vitamine D inférieurs à 12,3 ng/mL étaient prédicateurs d’une activité élevée de la maladie et des niveaux de vitamine D plus grands que 17,9 ng / mL étaient prédicateurs d'une activité faible de la maladie.

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RÉFÉRENCE: 
Veuillez lire l'article complet  (en anglais seulement) : 
Dis Markers. 2015;2015:260725. doi: 10.1155/2015/260725. Epub 2015 May 10.
Vitamin D Is a Good Marker for Disease Activity of Rheumatoid Arthritis Disease.
Azzeh FS1, Kensara OA1.
Author information
​Abstract
AIM:This study was conducted to find out the optimal vitamin D cutoff point in predicting activity of RA disease.
MATERIALS AND METHODS: 
One hundred and two rheumatoid arthritis Saudi patients of both genders were recruited in this study. Vitamin D as 25-hydroxy-vitamin D [25(OH)D] was measured and serum level less than 20 ng/mL defined as deficient patient. 
Disease activity was measured based on the disease activity score index of a 28-joint count (DAS28) using serum erythrocyte sedimentation rate levels. Receiver operating characteristic (ROC) curves were used to determine the optimal vitamin D cutoff points for identifying disease activity.
RESULTS:
It has been observed that vitamin D levels were lower (P < 0.05) in patients with high disease activity. A significant inverse correlation between serum 25(OH)D levels and DAS28 (r = -0.277, P = 0.014) was shown. ROC curves results showed that vitamin D less than 12.3 ng/mL predicted high disease activity, and vitamin D more than 17.9 ng/mL predicted low disease activity, with good sensitivity and accuracy results regarding vitamin D.
CONCLUSION:Study results concluded that vitamin D is a good predictor of RA disease activity in Saudi patients.

​PUBMED link:
http://www.ncbi.nlm.nih.gov/pubmed/26063950