 The results demonstrated that 1,25(OH)2D3 deficiency could induce colon inflammation, which may result from increased oxidative stress and DNA damage, subsequently, induced cell senescence and overproduction of senescence-associated secretory factors. 1,25(OH)2D3 may play an important role in preventing the development and progression of colon inflammation and colon cancer. Abstract
Epidemiological studies showed that 1,25-Dihydroxyvitamin D[1,25(OH)2D3] insufficiency appears to be associated with aging and colon cancer while underlying biological mechanisms remain largely unknown. Inflammatory bowel disease is one of the risk factors for colon cancer. In this study, we investigated whether 1,25(OH)2D3 deficiency has an impact on the colon of 25-hydroxyvitamin D 1α-hydroxylase knockout [Cyp27b1(-/-)] mice fed on a rescue diet (high calcium, phosphate, and lactose) from weaning to 10 months of age. We found that 1,25(OH)2D3 deficient mice displayed significant colon inflammation phenotypes including shortened colon length, thinned and disordered mucosal structure, and inflammatory cell infiltration. DNA damage, cellular senescence and the production of senescence-associated inflammatory cytokines were also increased significantly in the colon of Cyp27b1(-/-)mice. Furthermore, the levels of ROS in the colon were increased significantly, whereas the expression levels of antioxidative genes were down-regulated dramatically in the colon of Cyp27b1(-/-)mice. Taken together, our results demonstrated that 1,25(OH)2D3 deficiency could induce colon inflammation, which may result from increased oxidative stress and DNA damage, subsequently, induced cell senescence and overproduction of senescence-associated secretory factors. Therefore, our findings suggest that 1,25(OH)2D3 may play an important role in preventing the development and progression of colon inflammation and colon cancer. REFERENCE: PLoS One. 2016 Jan 20;11(1):e0146426. doi: 10.1371/journal.pone.0146426. eCollection 2016. 1,25(OH)2D3 Deficiency Induces Colon Inflammation via Secretion of Senescence-Associated Inflammatory Cytokines. Liu Y1, Chen L1, Zhi C1, Shen M2, Sun W1, Miao D1, Yuan X1.  By Richard Drucker, PhD
http://www.nutritionalwellness.com/archives/2006/jul/07_depleted_soil.php
Inorganic (synthetic/dead), ammonium-based fertilizers, along with herbicides and pesticides, kill the precious microorganisms in the soil that are essential to the creation of organic (carbon-based/living) mineral complexes. We have done more than simply use up the available trace minerals in our soils (those in the form of organic complexes). WE ALSO HAVE DESTROYED THE MEANS OF REPLENISHING THESE SOIL-BASED MICROORGANISMS. It is also easy to understand what Linus Pauling (twice awarded the Nobel Prize in medicine) meant when he explained to the 74th Congress of the United Sates, "Every ailment, every sickness and every disease can be traced back to an organic trace mineral deficiency." 17. SOIL MINERAL DEPLETION - CAN A HEALTHY DIET BE SUFFICIENT IN TODAY'S WORLD ? 18. SOIL DEPLETION  High selenium yeast supplementation (200 mug/d) was evaluated in a double-blind, randomized, placebo-controlled trial. Intention-to-treat analyses assessed the effect on HIV-1 viral load and CD4 count after 9 months of treatment.
Selenium-treated subjects whose serum selenium increase was greater than 26.1 microg/L evidenced excellent treatment adherence, no change in HIV-1 viral load, and an increase in CD4 count. Daily selenium supplementation can suppress the progression of HIV-1 viral burden and provide indirect improvement of CD4 (a certain type of white cells) count. The results support the use of selenium as a simple, inexpensive, and safe adjunct therapy in HIV spectrum disease. REFERENCE: Arch Intern Med. 2007 Jan 22;167(2):148-54. Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation: a randomized controlled trial. Hurwitz BE1, Klaus JR, Llabre MM, Gonzalez A, Lawrence PJ, Maher KJ, Greeson JM, Baum MK, Shor-Posner G, Skyler JS, Schneiderman N.  Among diabetics, infectious illness occurred in 93% of those receiving placebo and in 17% of those receiving multivitamin and mineral supplement. Abstract
BACKGROUND: Use of multivitamin and mineral supplements is common among U.S. adults, yet few well-designed trials have assessed the reputed benefits. OBJECTIVE: To determine the effect of a daily multivitamin and mineral supplement on infection and well-being. DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Primary care clinics at two medical centers in North Carolina. PARTICIPANTS: 130 community-dwelling adults stratified by age (45 to 64 years or >or=65 years) and presence of type 2 diabetes mellitus. INTERVENTION: Multivitamin and mineral supplement or placebo taken daily for 1 year. MEASUREMENTS: Incidence of participant-reported symptoms of infection, incidence of infection-associated absenteeism, and scores on the physical and mental health subscales of the Medical Outcomes Study 12-Item Short Form. RESULTS: More participants receiving placebo reported an infectious illness over the study year than did participants receiving multivitamin and mineral supplements (73% vs. 43%; P < 0.001). Infection-related absenteeism was also higher in the placebo group than in the treatment group (57% vs. 21%; P < 0.001). Participants with type 2 diabetes mellitus (n = 51) accounted for this finding. Among diabetic participants receiving placebo, 93% reported an infection compared with 17% of those receiving supplements (P < 0.001). Medical Outcomes Study 12-Item Short Form scores did not differ between the treatment and placebo groups. CONCLUSIONS: A multivitamin and mineral supplement reduced the incidence of participant-reported infection and related absenteeism in a sample of participants with type 2 diabetes mellitus and a high prevalence of subclinical micronutrient deficiency. A larger clinical trial is needed to determine whether these findings can be replicated not only in diabetic persons but also in any population with a high rate of suboptimal nutrition or potential underlying disease impairment. REFERENCE: Ann Intern Med. 2003 Mar 4;138(5):365-71. Effect of a multivitamin and mineral supplement on infection and quality of life. A randomized, double-blind, placebo-controlled trial. Barringer TA1, Kirk JK, Santaniello AC, Foley KL, Michielutte R.  Salivary melatonin levels varied according to the degree of periodontal disease. As the degree of periodontal disease increased, the salivary melatonin level decreased, indicating that melatonin may act to protect the body from external bacterial insults. Therefore, melatonin may be potentially valuable in the treatment of periodontal diseases. Abstract
BACKGROUND: Melatonin possesses antioxidant, free-radical scavenging, and immunoenhancing properties that promote fibroblast activity and bone regeneration. The aim of this study was to examine the possible links between salivary melatonin levels and the severity of periodontal disease using the community periodontal index (CPI). METHODS: Thirty-seven patients with different degrees of periodontal disease were studied. Salivary and plasma melatonin levels (by radioimmunoassay), salivary/plasma melatonin ratio, and CPI status were collected for each patient. The Spearman correlation coefficient was used to analyze relationships among variables. RESULTS: Data showed a significant correlation between CPI and salivary/plasma melatonin ratios. When saliva volume was controlled for, a significant correlation (P<0.05) was found between lower salivary melatonin and a worse CPI. This finding suggests that melatonin may act as a protector against free radicals produced by inflammatory periodontal diseases. CONCLUSIONS: Salivary melatonin levels varied according to the degree of periodontal disease. As the degree of periodontal disease increased, the salivary melatonin level decreased, indicating that melatonin may act to protect the body from external bacterial insults. Therefore, melatonin may be potentially valuable in the treatment of periodontal diseases, although further research is required to validate this hypothesis. REFERENCE: J Periodontol. 2006 Sep;77(9):1533-8. Relationship between salivary melatonin and severity of periodontal disease. Cutando A1, Galindo P, Gómez-Moreno G, Arana C, Bolaños J, Acuña-Castroviejo D, Wang HL.  Presented by Mr. Fletcher June 1 1936 and Ordered to be Printed by the United States Government Printing Office Washington: 1936 During the 74th Congress, Second Session, Document No. 264
IT IS BAD NEWS TO LEARN FROM OUR LEADING AUTHORITIES THAT 99% OF THE AMERICAN PEOPLE ARE DEFICIENT IN THESE MINERALS, AND THAT A MARKED DEFICIENCY IN ANY ONE OF THE MORE IMPORTANT MINERALS ACTUALLY RESULTS IN DISEASE. Any upset of the balance, any considerable lack of one or another element, however microscopic the body requirement may be, and we sicken, suffer, shorten our lives. Dr. Sherman of Columbia University asserts that 50% of the American people are starving for calcium. A recent article in the Journal of the American Medical Association stated that out of 4,000 cases in New York Hospital, only 2 were not suffering from a lack of calcium. Many States show a marked reduction in the productive capacity of the soil * * * in many districts amounting to a 25% to 50%reduction in the last 50 years * * *. Some areas show a 10 FOLD variation in calcium. Some show a 60 FOLD variation in phosphorus * * *. Authorities * * * see soil depletion, barren livestock, increased human death rate due to heart disease, deformities, arthritis, increased dental caries, all due to lack of essential minerals in plant food. "We know that vitamins are complex chemical substances which are indispensable to nutrition, and that each of them is of importance for normal function of some special structure in the body. DISORDERS AND DISEASE RESULT FROM ANY VITAMIN DEFICIENCY. It is not commonly realized, however, that vitamins control the body's appropriation of minerals, and in the absence of minerals they have no function to perform. Lacking vitamins, the system can make some use of minerals, but lacking minerals, vitamins are useless." This discovery is one of the latest and most important contributions of science to the problem of human health. -- Senate Document No. 264, 1936! http://www.senatedocument264.com/  No nutritional program is complete without a high-quality source of beneficial omega-3 fatty acids, which are lacking in the typical Western diet. Imagine if you are deficient in Omega 3 !
The cells in your body have a phospholipid bilayer that acts as a gatekeeper between the inside and outside of the cell—keeping things out or letting them in. As key components of that bilayer, omega-3 and omega-6 fatty acids from our diet play a significant role in maintaining our good health at the most basic level. It is important to maintain an appropriate 1:1 ratio of omega-3 and omega-6, as these two substances work together to promote health. However, average diets contain significantly more omega-6. The omega-3 long-chain fatty acids are the biosynthetic precursors of a family of compounds called eicosanoids (prostaglandins, thromboxanes, and leukotrienes). These hormone-like substances are a good source of omega-3 fatty acids for the maintenance of good health. Ratios of omega-3s to omega-6s from the diet help support brain function. Neural phospholipid membranes selectively uptake DHA, and it is concentrated in the photoreceptors and some cell-signalling sites. EPA and DHA are long-chain fatty acids whose function in the body includes helping maintain healthy highdensity lipoprotein and triglyceride levels in the plasma, which are important for supporting healthy arterial function and blood flow. Many large-scale epidemiological studies and randomized controlled studies have shown that omega-3 fatty acids from fish support cardiovascular health. These long-chain fatty acids are so important, in fact, that many commercially prepared infant formulas are now fortified with DHA to support health and nervous system development. |
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