Cumulative damage to tissues, mediated by reactive oxygen species, has been implicated as a pathway that leads to many of the degenerative changes associated with aging.
640 participants received complete assessments. Incident and progressive osteoarthritis (OA) occurred in 81 and 68 knees, respectively.
A 3-fold reduction in risk of OA progression was found for both the middle tertile and highest tertile of vitamin C intake. This related predominantly to a reduced risk of cartilage loss.
Those with high vitamin C intake also had a reduced risk of developing knee pain. A reduction in risk of OA progression was seen for beta carotene and vitamin E intake, but was less consistent. No significant associations were observed for the nonantioxidant nutrients.
High intake of antioxidant micronutrients, especially vitamin C, may reduce the risk of cartilage loss and disease progression in people with OA. We found no effect of antioxidant nutrients on incident OA. These preliminary findings warrant confirmation.
Experimental evidence suggests that acute parenteral administration of high-dose ascorbic acid has beneficial vascular effects in type 2 diabetes. We studied the hemodynamic effects of chronic oral supplementation in this condition.
Thirty patients, 45 to 70 years of age, with type 2 diabetes, were randomly assigned in a double-blind manner to receive 500 mg ascorbic acid daily by mouth or placebo. Patients were studied at baseline and after 4 weeks of assigned treatment.
This study show that after 1 month, oral ascorbic acid lowered arterial blood pressure and improved arterial stiffness in patients with type 2 diabetes.
As strict control of blood pressure reduces cardiovascular risk in diabetes, ascorbic acid supplementation may potentially be a useful and inexpensive adjunctive therapy.
Vitamin D3 and metformin are widely used in humans for regulating mineral metabolism and as an antidiabetic drug, respectively; and both of them have been shown to have chemopreventive effects against various tumors.
This study was designed to investigate the potential synergistic chemopreventive effects of vitamin D3 and metformin against the development of early colon neoplasia in two models.
Compared with either vitamin D3 or metformin alone, combined use of vitamin D3 and metformin showed more pronounced effect in reducing the numbers of aberrant crypt foci (ACF) and tumor in the colon.
The most prominent inhibitory effects were observed in the vitamin D3 medium dose (100 IU/kg/d) and metformin medium dose (120 mg/kg/d) combination group.
The findings show that the combined use of vitamin D3 and metformin exhibits synergistic effects against the development of early colon neoplasia. They suggest that the combined use of vitamin D3 and metformin may represent a novel strategy for chemoprevention of colorectal cancer.
Cancer Prev Res (Phila). 2015 Feb;8(2):139-48. doi: 10.1158/1940-6207.CAPR-14-0128. Epub 2014 Nov 21.
Combined use of vitamin D3 and metformin exhibits synergistic chemopreventive effects on colorectal neoplasia in rats and mice.
Li W1, Wang QL2, Liu X2, Dong SH2, Li HX2, Li CY2, Guo LS2, Gao JM2, Berger NA3, Li L4, Ma L5, Wu YJ6.
Following the change of dietary structure and living style, metabolic syndrome (MetS) has become increasingly common in China, especially in women, who have abnormal plasma lipid profiles with increased levels of oxidative stress. Vitamin E (VitE) is a powerful chain-breaking antioxidant, which may be a protective factor against oxidative stress-related diseases. This study investigated the effects of three different dosages of tocopherol supplementation (100 IU /day, 200 IU /day, 300 IU /day) for 4 months in Chinese women with MetS. The plasma VitE concentrations increased significantly after the 4 months of supplementation.
The effects of three different dosages of tocopherol supplementation (100 IU /day, 200 IU /day, 300 IU /day) for 4 months in Chinese women with metabolic syndrome :
Studies have shown that vitamin D could have a role in breast cancer survival; however, the evidence of the relationship between patients' vitamin D levels and their survival has been inconsistent. This meta-analysis explores possible dose-response relationships between vitamin D levels and overall survival by allowing for differences in vitamin D levels among populations of the various studies.
6 studies with a total number of 5984 patients were identified. At or above a 23.3 nmol/L threshold, for a 10 nmol/L, 20 nmol/L, or 25 nmol/L increment in circulating 25-OH-D levels, the risk of breast cancer overall mortality decreased by 6%, 12%, and 14%, respectively.
These findings suggest that there is a highly significant linear dose-response relationship between circulating 25-OH-D levels and overall survival in patients with breast cancer.
Current traditional therapies (antihistamines, decongestants, cortisone, etc.) is not satisfactory and can cause a variety of complications such as sedation, impaired learning/memory capacity, cardiac problems and the inability to perform daily activities.
Nineteen studies were selected. Lower vitamin D levels were associated with a higher allergic rhinitis prevalence only in children.
The pooled mean vitamin D level in patients with allergic rhinitis was lower than that of controls only in children.
Psoriasis is influenced by: environmental factors (infections and stress), poor dietary and exercise habits, smoking, alcohol consumption and food intolerances such as gluten sensitivity.
This chronic disease has potential systemic complications such as abnormal plasma lipid metabolism, cardiovascular disease, hypertension, chronic systemic inflammation, obesity, higher body mass index, nutritional deficiencies and even nutrient-drug interactions.
Because of the many treatment-related adverse events, patients with psoriasis are often unsatisfied with traditional medical treatments and are turning to the use of alternative and complementary medicine such as nutritional supplements.
Supplementation with antioxidants coenzyme Q(10), vitamin E, and selenium could be feasible for the management of patients with severe forms of psoriasis.
Complementary and alternative medicine has been used either alone or in combination with conventional therapies in patients with depression.
Studies suggest that acupuncture, mindfulness therapies, exercise, antioxidants, vitamins and minerals are effective in the treatment of mood disorders.
More and more studies demonstrate a significant association between modifiable lifestyle factors and depression risk.
Integrative medicine approaches can be used effectively in mild to moderate depression and in treatment-resistant depression. Even if complementary and alternative medicine therapies are not the primary treatment of mood disorders, the science is showing that such treatments should be taken in consideration.
The studies available suggest folic acid has either antidepressant properties or can act as an augmenting agent for standard antidepressant treatment. Folic acid is a simple method of greatly improving the antidepressant action of fluoxetine and probably other antidepressants.
J Affect Disord. 2000 Nov;60(2):121-30.
Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.
Coppen A1, Bailey J.
Hum Psychopharmacol. 2004 Oct;19(7):477-88.Folic acid: neurochemistry, metabolism and relationship to depression.
Paul RT1, McDonnell AP, Kelly CB.
Antioxidants can neutralize the reactive oxygen species and are used to treat inflammatory disease involving oxidative stress, such as periodontitis.
Supplements such as coenzyme Q10 can reduce periodontal inflammation.
Nutritional therapy should be considered as a new adjuvant therapy for the regeneration of lost periodontal tissues and the reduction of gingival inflammation.
Coenzyme Q10 serves as an endogenous antioxidant and its increased concentration in the diseased gingiva effectively suppresses advanced periodontal inflammation. There was a significant improvement in all clinical parameters in the test sites seen at the end of the 4-week period.
Sites with bleeding on probing were reduced more in the test group than in the control group. Coenzyme Q10 can be said to have a beneficial effect on periodontitis when used as an adjunct to scaling and root planing.
J Indian Soc Periodontol. 2014 Jul;18(4):461-5. doi: 10.4103/0972-124X.138690.
A comparative evaluation of topical and intrasulcular application of coenzyme Q10 (Perio Q™) gel in chronic periodontitis patients: A clinical study.
Sale ST1, Parvez H1, Yeltiwar RK1, Vivekanandan G1, Pundir AJ1, Jain P1.
Menopause is a natural condition experienced by every woman as she get older. It is part of a woman's natural aging process when the ovaries are producing lower levels of sexual hormones (estrogen and progesterone), the ovulation process is disturbed (no ovulation each month) and menstruations stops.
Usually, menopause is declared when it has been 12 months in a row since your last menstrual period.
Menopause is often accompanied by hot flashes, irritability, degenerative processes (arteriosclerosis, cardiovascular diseases), osteoporosis, weight gain, sleep disorder, atrophic changes of the skin, hair loss, etc.
Clinical evidence exists on the effectiveness of using supplements in postmenopausal women. One of these supplements is the GRAPE SEED EXTRACT.
Grape seed extract tablets containing either low-dose (100 mg/d) or high-dose (200 mg/d) proanthocyanidin, or placebo, for 8 weeks : grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure in middle-aged women.
Menopause. 2014 Sep;21(9):990-6. doi: 10.1097/GME.0000000000000200.
Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study.
Terauchi M1, Horiguchi N, Kajiyama A, Akiyoshi M, Owa Y, Kato K, Kubota T.
The informations and advices published or made available through drsuciu.com web site are not intended to replace the services of a physician, or any other therapist nor does it constitute a doctor-patient relationship.
You should not use the information on this website for diagnosing or treating a medical condition or a health problem
We advise you to consult your doctor regarding all matters relating to your health and in particular regarding the existence of symptoms that may require diagnosis or medical care