Rôle de la vitamine D et du calcium dans le diabète de type 2

De nombreuses études ont démontré que le stress oxydatif est associé au diabète de type 2. Il existe des preuves biochimiques convaincantes qui suggèrent que les espèces réactives de l’oxygène peuvent même jouer un rôle dans la pathogenèse du diabète de type 2.

Un apport quotidien combiné de > 1200 mg de calcium et > 800 UI de vitamine D a été associé à une diminution du risque de 33% du diabète de type 2.

DIABÈTE: quels suppléments devrais-je prendre ?

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Abstract
OBJECTIVE:
The purpose of this study was to prospectively examine the association between vitamin D and calcium intake and risk of type 2 diabetes.
RESEARCH DESIGN AND METHODS:
In the Nurses' Health Study, we followed 83,779 women who had no history of diabetes, cardiovascular disease, or cancer at baseline for the development of type 2 diabetes. Vitamin D and calcium intake from diet and supplements was assessed every 2-4 years. During 20 years of follow-up, we documented 4,843 incident cases of type 2 diabetes.
RESULTS:
After adjusting for multiple potential confounders, there was no association between total vitamin D intake and type 2 diabetes. However, the relative risk (RR) of type 2 diabetes was 0.87 (95% CI 0.75-1.00; P for trend = 0.04) comparing the highest with the lowest category of vitamin D intake from supplements. The multivariate RRs of type 2 diabetes were 0.79 (0.70-0.90; P for trend <0.001) comparing the highest with the lowest category of calcium intake from all sources and 0.82 (0.72-0.92; P for trend <0.001) comparing the highest with the lowest category of calcium intake from supplements.
A combined daily intake of >1,200 mg calcium and >800 IU vitamin D was associated with a 33% lower risk of type 2 diabetes with RR of 0.67 (0.49-0.90) compared with an intake of <600 mg and 400 IU calcium and vitamin D, respectively.
CONCLUSIONS:
The results of this large prospective study suggest a potential beneficial role for both vitamin D and calcium intake in reducing the risk of type 2 diabetes.

Diabetes Care. 2006 Mar;29(3):650-6.
Vitamin D and calcium intake in relation to type 2 diabetes in women.
Pittas AG1, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB.​