Nous ne pouvons pas vivre sans cholestérol. Le cholestérol est un composant naturel de toutes les cellules du corps et est essentiel à la production d’hormones sexuelles ainsi qu’au métabolisme de la vitamine D.
Le cholestérol corporel a 2 origines: la source endogène - le foie est l'endroit principal où le cholestérol est synthétisé et la source exogène provenant de l'alimentation.
Il existe deux types de cholestérol, le HDL (lipoprotéines de haute densité, ou «bon» cholestérol) et le LDL (lipoprotéines de basse densité, ou «mauvais» cholestérol). Le cholestérol LDL (mauvais) ramasse les molécules de cholestérol du foie et le livre aux cellules. Le HDL (bon) cholestérol supprime l'excès de cholestérol du sang et le ramène vers le foie
L'étude conclut que l'administration combinée d'atorvastatine et de CoQ10 a amélioré les paramètres biochimiques, la fonction hépatique et la respiration mitochondriale chez les rats hypercholestérolémiques. Cet effet bénéfique de la CoQ10 doit être combiné avec le traitement de statine chez le patient avec des niveaux élevés de cholestérol.
Le cholestérol corporel a 2 origines: la source endogène - le foie est l'endroit principal où le cholestérol est synthétisé et la source exogène provenant de l'alimentation.
Il existe deux types de cholestérol, le HDL (lipoprotéines de haute densité, ou «bon» cholestérol) et le LDL (lipoprotéines de basse densité, ou «mauvais» cholestérol). Le cholestérol LDL (mauvais) ramasse les molécules de cholestérol du foie et le livre aux cellules. Le HDL (bon) cholestérol supprime l'excès de cholestérol du sang et le ramène vers le foie
L'étude conclut que l'administration combinée d'atorvastatine et de CoQ10 a amélioré les paramètres biochimiques, la fonction hépatique et la respiration mitochondriale chez les rats hypercholestérolémiques. Cet effet bénéfique de la CoQ10 doit être combiné avec le traitement de statine chez le patient avec des niveaux élevés de cholestérol.
RÉFÉRENCE
Veuillez lire l'article complet (en anglais seulement) :
Lipids Health Dis. 2014 Jan 25;13:22. doi: 10.1186/1476-511X-13-22.
Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet.
Jiménez-Santos MA1, Juárez-Rojop IE, Tovilla-Zárate CA, Espinosa-García MT, Juárez-Oropeza MA, Ramón-Frías T, Bermúdez-Ocaña DY, Díaz-Zagoya JC.
Abstract
BACKGROUND:
The aim of this study was to evaluate the actions of coenzyme Q10 (CoQ10) on rats with a cholesterol-rich diet (HD) and high doses of atorvastatin (ATV, 0.2, 0.56 or 1.42 mg/day).
METHODS:
Two experiments were done, the first one without coenzyme Q10 supplementation. On the second experiment all groups received coenzyme Q10 0.57 mg/day as supplement. After a 6-week treatment animals were sacrificed, blood and liver were analyzed and liver mitochondria were isolated and its oxygen consumption was evaluated in state 3 (phosphorylating state) and state 4 (resting state) in order to calculate the respiratory control (RC).
RESULTS:
HD increased serum and hepatic cholesterol levels in rats with or without CoQ10. ATV reduced these values but CoQ10 improved even more serum and liver cholesterol. Triacylglycerols (TAG) were also lower in blood and liver of rats with ATV + CoQ10. HDL-C decreased in HD rats. Treatment with ATV maintained HDL-C levels. However, these values were lower in HD + CoQ10 compared to control diet (CD) + CoQ10. RC was lessened in liver mitochondria of HD. The administration of ATV increased RC. All groups supplemented with CoQ10 showed an increment in RC. In conclusion, the combined administration of ATV and CoQ10 improved biochemical parameters, liver function and mitochondrial respiration in hypercholesterolemic rats.
CONCLUSIONS:
Our results suggest a potential beneficial effect of CoQ10 supplementation in hypercholesterolemic rats that also receive atorvastatin. This beneficial effect of CoQ10 must be combined with statin treatment in patient with high levels of cholesterol.
Veuillez lire l'article complet (en anglais seulement) :
Lipids Health Dis. 2014 Jan 25;13:22. doi: 10.1186/1476-511X-13-22.
Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet.
Jiménez-Santos MA1, Juárez-Rojop IE, Tovilla-Zárate CA, Espinosa-García MT, Juárez-Oropeza MA, Ramón-Frías T, Bermúdez-Ocaña DY, Díaz-Zagoya JC.
Abstract
BACKGROUND:
The aim of this study was to evaluate the actions of coenzyme Q10 (CoQ10) on rats with a cholesterol-rich diet (HD) and high doses of atorvastatin (ATV, 0.2, 0.56 or 1.42 mg/day).
METHODS:
Two experiments were done, the first one without coenzyme Q10 supplementation. On the second experiment all groups received coenzyme Q10 0.57 mg/day as supplement. After a 6-week treatment animals were sacrificed, blood and liver were analyzed and liver mitochondria were isolated and its oxygen consumption was evaluated in state 3 (phosphorylating state) and state 4 (resting state) in order to calculate the respiratory control (RC).
RESULTS:
HD increased serum and hepatic cholesterol levels in rats with or without CoQ10. ATV reduced these values but CoQ10 improved even more serum and liver cholesterol. Triacylglycerols (TAG) were also lower in blood and liver of rats with ATV + CoQ10. HDL-C decreased in HD rats. Treatment with ATV maintained HDL-C levels. However, these values were lower in HD + CoQ10 compared to control diet (CD) + CoQ10. RC was lessened in liver mitochondria of HD. The administration of ATV increased RC. All groups supplemented with CoQ10 showed an increment in RC. In conclusion, the combined administration of ATV and CoQ10 improved biochemical parameters, liver function and mitochondrial respiration in hypercholesterolemic rats.
CONCLUSIONS:
Our results suggest a potential beneficial effect of CoQ10 supplementation in hypercholesterolemic rats that also receive atorvastatin. This beneficial effect of CoQ10 must be combined with statin treatment in patient with high levels of cholesterol.
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