Coenzyme Q10 application in periodontitis

Antioxidants can neutralize the reactive oxygen species and are used to treat inflammatory disease involving oxidative stress, such as periodontitis.
Supplements such as coenzyme Q10 can reduce periodontal inflammation. 
Nutritional therapy should be considered as a new adjuvant therapy for the regeneration of lost periodontal tissues and the reduction of gingival inflammation. 
Coenzyme Q10 serves as an endogenous antioxidant and its increased concentration in the diseased gingiva effectively suppresses advanced periodontal inflammation. There was a significant improvement in all clinical parameters in the test sites seen at the end of the 4-week period.
​Sites with bleeding on probing were reduced more in the test group than in the control group. Coenzyme Q10 can be said to have a beneficial effect on periodontitis when used as an adjunct to scaling and root planing.

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REFERENCE: 
​J Indian Soc Periodontol. 2014 Jul;18(4):461-5. doi: 10.4103/0972-124X.138690.
A comparative evaluation of topical and intrasulcular application of coenzyme Q10 (Perio Q™) gel in chronic periodontitis patients: A clinical study.
Sale ST1, Parvez H1, Yeltiwar RK1, Vivekanandan G1, Pundir AJ1, Jain P1.