Vitamin E and total cholesterol level

Following the change of dietary structure and living style, metabolic syndrome (MetS) has become increasingly common in China, especially in women, who have abnormal plasma lipid profiles with increased levels of oxidative stress. Vitamin E (VitE) is a powerful chain-breaking antioxidant, which may be a protective factor against oxidative stress-related diseases. This study investigated the effects of three different dosages of tocopherol supplementation (100 IU /day, 200 IU /day, 300 IU /day) for 4 months in Chinese women with MetS. The plasma VitE concentrations increased significantly after the 4 months of supplementation. 
The effects of three different dosages of tocopherol supplementation (100 IU /day, 200 IU /day, 300 IU /day) for 4 months in Chinese women with metabolic syndrome :

• the plasma Vitamin E concentrations increased significantly after the 4 months of supplementation;
• the decreases in plasma total cholesterol were significant in 200 IU/day and 300 IU/day Vitamin E groups. 

Vitamin E provided marked benefits in reducing oxidative stress levels and improving lipid status in women with MetS. Although no dose-effect relationship was observed, 300 IU Vitamin E per day showed the optimal effect. 

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REFERENCE: 
​Int J Vitam Nutr Res. 2010 Jun;80(3):178-87. doi: 10.1024/0300-9831/a000015.
Effects of vitamin E on plasma lipid status and oxidative stress in Chinese women with metabolic syndrome.
Wang Q1, Sun Y, Ma A, Li Y, Han X, Liang H.