Grape seed extract benefits in menopause

Menopause is a natural condition experienced by every woman as she get older. It is part of a woman's natural aging process when the ovaries are producing lower levels of sexual hormones (estrogen and progesterone), the ovulation process is disturbed (no ovulation each month) and menstruations stops.
​Usually, menopause is declared when it has been 12 months in a row since your last menstrual period.
Menopause is often accompanied by hot flashes, irritability, degenerative processes (arteriosclerosis, cardiovascular diseases), osteoporosis, weight gain, sleep disorder, atrophic changes of the skin, hair loss, etc. 
Clinical evidence exists on the effectiveness of using supplements in postmenopausal women. One of these supplements is the GRAPE SEED EXTRACT.
Grape seed extract tablets containing either low-dose (100 mg/d) or high-dose (200 mg/d) proanthocyanidin, or placebo, for 8 weeks : grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure in middle-aged women.

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REFERENCE: 
​Menopause. 2014 Sep;21(9):990-6. doi: 10.1097/GME.0000000000000200.
Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study.
​Terauchi M1, Horiguchi N, Kajiyama A, Akiyoshi M, Owa Y, Kato K, Kubota T.