Periodontal disease is a progressive, inflammatory disease affecting tooth supporting tissues. It is associated with oral bacterial dysbiosis, dysregulation of immune response (chronic inflammation), oxidative stress, periodontium destruction and tooth loss.
Oxidative stress is defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defences. Patients with periodontal disease seems to have a high level of oxidative stress produces by a large number of free radicals (toxins) and a reduced antioxidant capacity.
Ascorbic acid deficiency has been shown to be a conditioning factor in the development of gingivitis.
When humans are placed on ascorbic acid deficient diets there is increased edema, redness and swelling of the gingiva. These changes have been attributed to deficient collagen production by gingival blood vessels.
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