Le STRESS OXYDATIF est défini comme UNE PERTURBATION DANS L'ÉQUILIBRE entre les radicaux libres et les défenses antioxydantes. Il a été identifié comme étant un facteur pertinent dans le développement du cancer.
Un nombre croissant de preuves démontre que les dérivés réactifs de l’oxygène sont capables de causer des dommages aux membranes cellulaires, aux mitochondries, et aux macromolécules y compris les protéines, les lipides et l'ADN. L'accumulation de tous ces dommages peut contribuer à la cancérogenèse.
L' acide gras essentiel Oméga 3, l'acide docosahexaénoïque (DHA), démontre une activité anticancéreuse en induisant l'apoptose de certaines cellules cancéreuses humaines sans toxicité vis-à-vis des cellules normales. Le DHA démontre un effet inhibiteur variable sur la croissance des cellules cancéreuses en fonction des propriétés moléculaires des cellules et du degré de malignité.
Un nombre croissant de preuves démontre que les dérivés réactifs de l’oxygène sont capables de causer des dommages aux membranes cellulaires, aux mitochondries, et aux macromolécules y compris les protéines, les lipides et l'ADN. L'accumulation de tous ces dommages peut contribuer à la cancérogenèse.
L' acide gras essentiel Oméga 3, l'acide docosahexaénoïque (DHA), démontre une activité anticancéreuse en induisant l'apoptose de certaines cellules cancéreuses humaines sans toxicité vis-à-vis des cellules normales. Le DHA démontre un effet inhibiteur variable sur la croissance des cellules cancéreuses en fonction des propriétés moléculaires des cellules et du degré de malignité.
RÉFÉRENCE
Veuillez lire l'article complet (en anglais seulement) :
Int J Mol Sci. 2016 Aug 3;17(8). pii: E1257. doi: 10.3390/ijms17081257.
Docosahexaenoic Acid Induces Oxidative DNA Damage and Apoptosis, and Enhances the Chemosensitivity of Cancer Cells.
Song EA1, Kim H2.
Abstract
The human diet contains low amounts of ω-3 polyunsaturated fatty acids (PUFAs) and high amounts of ω-6 PUFAs, which has been reported to contribute to the incidence of cancer. Epidemiological studies have shown that a high consumption of fish oil or ω-3 PUFAs reduced the risk of colon, pancreatic, and endometrial cancers.
The ω-3 PUFA, docosahexaenoic acid (DHA), shows anticancer activity by inducing apoptosis of some human cancer cells without toxicity against normal cells. DHA induces oxidative stress and oxidative DNA adduct formation by depleting intracellular glutathione (GSH) and decreasing the mitochondrial function of cancer cells.
Oxidative DNA damage and DNA strand breaks activate DNA damage responses to repair the damaged DNA.
However, excessive DNA damage beyond the capacity of the DNA repair processes may initiate apoptotic signaling pathways and cell cycle arrest in cancer cells. DHA shows a variable inhibitory effect on cancer cell growth depending on the cells' molecular properties and degree of malignancy.
It has been shown to affect DNA repair processes including DNA-dependent protein kinases and mismatch repair in cancer cells. Moreover, DHA enhanced the efficacy of anticancer drugs by increasing drug uptake and suppressing survival pathways in cancer cells. In this review, DHA-induced oxidative DNA damage, apoptotic signaling, and enhancement of chemosensitivity in cancer cells will be discussed based on recent studies.
Veuillez lire l'article complet (en anglais seulement) :
Int J Mol Sci. 2016 Aug 3;17(8). pii: E1257. doi: 10.3390/ijms17081257.
Docosahexaenoic Acid Induces Oxidative DNA Damage and Apoptosis, and Enhances the Chemosensitivity of Cancer Cells.
Song EA1, Kim H2.
Abstract
The human diet contains low amounts of ω-3 polyunsaturated fatty acids (PUFAs) and high amounts of ω-6 PUFAs, which has been reported to contribute to the incidence of cancer. Epidemiological studies have shown that a high consumption of fish oil or ω-3 PUFAs reduced the risk of colon, pancreatic, and endometrial cancers.
The ω-3 PUFA, docosahexaenoic acid (DHA), shows anticancer activity by inducing apoptosis of some human cancer cells without toxicity against normal cells. DHA induces oxidative stress and oxidative DNA adduct formation by depleting intracellular glutathione (GSH) and decreasing the mitochondrial function of cancer cells.
Oxidative DNA damage and DNA strand breaks activate DNA damage responses to repair the damaged DNA.
However, excessive DNA damage beyond the capacity of the DNA repair processes may initiate apoptotic signaling pathways and cell cycle arrest in cancer cells. DHA shows a variable inhibitory effect on cancer cell growth depending on the cells' molecular properties and degree of malignancy.
It has been shown to affect DNA repair processes including DNA-dependent protein kinases and mismatch repair in cancer cells. Moreover, DHA enhanced the efficacy of anticancer drugs by increasing drug uptake and suppressing survival pathways in cancer cells. In this review, DHA-induced oxidative DNA damage, apoptotic signaling, and enhancement of chemosensitivity in cancer cells will be discussed based on recent studies.
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