 Administrarea orala timp de 5 zile inainte de interventia chirurgicala, a unui supliment bogat in acizi grasi Omega-3, poate imbunatati nu numai starea de nutritie preoperatorie ci si raspunsurile imune si inflamatorii preoperatorii si postoperatorii la pacientii care au cancer. Cititi articolul complet aici (numai in engleza) :
http://www.ncbi.nlm.nih.gov/pubmed/15925286 Nutrition. 2005 Jun;21(6):639-49. Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. Nakamura K1, Kariyazono H, Komokata T, Hamada N, Sakata R, Yamada K.  SCHIMBARILE ISTORICE IN CONCENTRATIA DE MINERALE DIN FRUCTE SI LEGUME
Autor Anne‐Marie Mayer http://dx.doi.org/10.1108/00070709710181540
 Regimul mediteranean reduce in mod semnificativ riscul de boli cardiovasculare. Cititi articolul in intregime (numai in engleza):
http://www.ncbi.nlm.nih.gov/pubmed/19903723 Am J Epidemiol. 2009 Dec 15;170(12):1518-29. doi: 10.1093/aje/kwp282. Epub 2009 Nov 10. Adherence to the Mediterranean diet and risk of coronary heart disease in the Spanish EPIC Cohort Study. Buckland G1, González CA, Agudo A, Vilardell M, Berenguer A, Amiano P, Ardanaz E, Arriola L, Barricarte A, Basterretxea M, Chirlaque MD, Cirera L,Dorronsoro M, Egües N, Huerta JM, Larrañaga N, Marin P, Martínez C, Molina E, Navarro C, Quirós JR, Rodriguez L, Sanchez MJ, Tormo MJ, Moreno-Iribas C.  Prin administrarea suplimentelor nutritive care contin molecule de inlocuire si antioxidanti, daunele oxidative de la nivelul membranelor celulare si reducerea cofactorilor din tesuturile normale pot fi reversate, ceea ce duce la restaurarea si protejarea functiilor celulare si implicit la reducerea efectelor adverse ale chimioterapiei. Administrarea moleculelor de inlocuire si a antioxidantilor atenueaza deteriorarea tesuturilor normale, cum ar fi tesutul cardiac si reduce efectele adverse ale tratamentului cancerului, fara diminuarea rezultatelor terapeutice. Cititi articolul scurt (numai in engleza) :
http://www.ncbi.nlm.nih.gov/pubmed/18058028 Clin Exp Metastasis. 2008;25(2):161-9. Epub 2007 Dec 5. Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by molecular replacement therapy. Nicolson GL1, Conklin KA. Cititi articolul in intregime : http://www.immed.org/JAN08Updates/NicolsonCCTR2.pdf  Luteina si zeaxantina pot reduce riscul de cataracta severa care necesita interventie chirurgicala. CITITI ARTICOLUL COMPLET AICI (numai in engleza) :
http://www.ncbi.nlm.nih.gov/pubmed/10500020 Am J Clin Nutr. 1999 Oct;70(4):509-16.A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women.Chasan-Taber L1, Willett WC, Seddon JM, Stampfer MJ, Rosner B, Colditz GA, Speizer FE, Hankinson SE.  SOLURI EPUIZATE SI ALIMENTE COMPROMISE
Richard Drucker, PhD http://www.nutritionalwellness.com/archives/2006/jul/07_depleted_soil.php
 Imbatranirea normala a organismului a fost definita de cercetatori ca fiind MENTINEREA sanatatii cognitive, fizice si mentale in stare buna si ABSENTA bolilor cronice majore la o varsta mai mare de 70 de ani. Am J Clin Nutr. 2014 Dec;100(6):1489-97. doi: 10.3945/ajcn.114.085605. Epub 2014 Oct 29.
Dietary flavonoid intake at midlife and healthy aging in women. Samieri C1, Sun Q1, Townsend MK1, Rimm EB1, Grodstein F1.  La pacientii cu astm bronsic, magneziul are o implicare substantiala in procesele antiinflamatorii si vasodilatatoare. J Asthma. 1998;35(7):525-36.Magnesium in the management of asthma: critical review of acute and chronic treatments, and Deutsches Medizinisches Zentrum's (DMZ's) clinical experience at the Dead Sea.
Harari M1, Barzillai R, Shani J.  Acizii grasi Omega-3 reprezinta agenti potentiali de prevenire pentru cancerul de colon recurent. Exista din ce in ce mai multe probe care sustin procesele tumorale, inclusiv cele colorectale sporadice, sun conduse de catre celulele stem care se reinnoiesc singure si nu numai atat, dar sunt rezistente la agentii chimioterapici. Aceste lucruri obliga la imbunatatirea strategiilor preventive si terapeutice in caz de cancer de colon. Acizii grasi polinesaturati Omega 3 Increasing evidence supports the contention that many malignancies, including sporadic colorectal cancer, are driven by the self-renewing, chemotherapy-resistant cancer stem/stem-like cells (CSC/CSLC), underscoring the need for improved preventive and therapeutic strategies targeting CSCs/CSLCs. Omega-3 polyunsaturated fatty acids (ω-3 PUFA), have been reported to inhibit the growth of primary tumors, but their potential as a preventive agent for recurring cancers is unexplored. The primary objectives of this investigation are (i) to examine whether eicosapentaenoic acid (EPA; one of the ω-3 PUFA) synergizes with FuOx (5-FU+Oxaliplatin), the backbone of colon cancer chemotherapy, and (ii) whether EPA by itself or in combination with conventional chemotherapy prevents the recurrence of colon cancer via eliminating/suppressing CSCs/CSLCs. FuOx-resistant (chemoresistant; CR) colon cancer cells, highly enriched in CSCs, were used for this study. Although EPA alone was effective, combination of EPA and FuOx was more potent in (i) inhibiting cell growth, colonosphere formation, and sphere-forming frequency, (ii) increasing sphere disintegration, (iii) suppressing the growth of SCID mice xenografts of CR colon cancer cells, and (iv) decreasing proinflammatory metabolites in mice. In addition, EPA + FuOx caused a reduction in CSC/CSLC population. The growth reduction by this regimen is the result of increased apoptosis as evidenced by PARP cleavage. Furthermore, increased pPTEN, decreased pAkt, normalization of β-catenin expression, localization, and transcriptional activity by EPA suggests a role for the PTEN-Akt axis and Wnt signaling in regulating this process. Our data suggest that EPA by itself or in combination with FuOx could be an effective preventive strategy for recurring colorectal cancer. doi: 10.1158/1940-6207.CAPR-14-0177. Epub 2014 Sep 5.Omega-3 fatty acid is a potential preventive agent for recurrent colon cancer.
Vasudevan A1, Yu Y2, Banerjee S3, Woods J1, Farhana L2, Rajendra SG1, Patel A1, Dyson G4, Levi E5, Maddipati KR6, Majumdar AP7, Nangia-Makker P7.  Un studiu din 1999 de la Universitatea din Wisconsin (SUA) a constatat ca AZOTUL PUS IN EXCES TIMP DE 3 DECENII in agricultura din America A DISTRUS O MARE PARTE A FERTILITATII SOLULUI, ASTFEL CA ACESTA A ''IMBATRANIT'' CU 5000 DE ANI.
http://www.organicconsumers.org/newsletter/organicview21.cfm  Pe baza datelor disponibile, se sugereaza ca speranta de viata a oamenilor poate fi crescuta semnificativ in secolul XXI prin optimizarea dietei si folosirea suplimentelor nutritionale. Datorita unui control mai bun asupra bolilor infectioase si a accesului catre o dieta mai nutritiva, speranta de viata in tarile dezvoltate a crescut dramatic inceoabd cu secolul 20.
Dar, chiar daca varsta medie a populatiei a crescut, incidenta bolilor degenerative cum ar fi boala Alzheimer, Parkinson, bolile cardiovasculare, cancerul, artrita, osteoporoza, hiperplazia benigna a prostatei, diabetul de tip 3 si degenerescenta maculara, a crescut. Sunt foarte multe studii care arata ca stresul oxidativ si anumite deficiente nutritionale ar putea contribui la procesul de imbatranire si la aparitia bolilor dependente de varsta. Pe baza datelor disponibile, se sugereaza ca speranta de viata a oamenilor poate fi crescuta semnificativ in secolul XXI prin optimizarea dietei si folosirea suplimentelor nutritionale. Exp Gerontol. 2000 Dec;35(9-10):1405-17. Nutraceutical interventions may delay aging and the age-related diseases. Villeponteau B1, Cockrell R, Feng J.  Studiile existente sustin ca stresul oxidativ poate juca un rol crucial in anomaliile cardiace si vasculare si ca terapia antioxidanta se poate dovedi a fi benefica in combaterea acestor probleme.
 La pacientii suferinzi de artroza, nivelul de vitamina E a fost semnificativ mai mic in lichidul sinovial. Int J Rheum Dis. 2009 Dec;12(4):324-8. doi: 10.1111/j.1756-185X.2009.01430.x.
Lipid peroxidation, glutathione, vitamin E, and antioxidant enzymes in synovial fluid from patients with osteoarthritis. Sutipornpalangkul W1, Morales NP, Charoencholvanich K, Harnroongroj T.  Nivelul seric scazut al vitaminei D este asociat cu un prognostic rezervat la pacientii cu tumori hematologice maligne, inclusiv in caz de limfom si leucemie.
Cell Physiol Biochem. 2015;35(5):1999-2005. doi: 10.1159/000374007. Epub 2015 Mar 27. Serum 25-hydroxyvitamin D levels and prognosis in hematological malignancies: a systematic review and meta-analysis. Wang W1, Li G, He X, Gao J, Wang R, Wang Y, Zhao W.  ''Continutul in fier al produselor din carne a scazut in medie cu 54%. Declinul de doua cifre in calitatea nutrientilor din carne si produse lactate reprezinta unul dintre primele indicii ca un consum de cereale si furaje care contine mai putine nutrimente are un impact masurabil asupra animalelor care le mananca, si, probabil, in al doilea rand, asupra persoanelelor care consuma carne si laptele de la aceste animale. "
http://featuresblogs.chicagotribune.com/features_julieshealthclub/2008/02/more-food-fewer.html  Lungimea telomerelor (secventele de ADN de la sfarsitul bratelor cromozomilor) poate fi un indiciu a imbatranirii biologice.
Am J Clin Nutr. 2009 Jun;89(6):1857-63. doi: 10.3945/ajcn.2008.26986. Epub 2009 Mar 11.
Multivitamin use and telomere length in women. Xu Q1, Parks CG, DeRoo LA, Cawthon RM, Sandler DP, Chen H.  SCHIMBARILE PROCENTUALE IN CONTINUTUL NUTRIMENTELOR FRUCTELOR SI LEGUMELOR INTRE 1951-1999:
O banana are:
TODAY'S FRUITS, VEGETABLES LACK YESTERDAY'S NUTRITION ANDRÉ PICARD http://www.theglobeandmail.com/life/todays-fruits-vegetables-lack-yesterdays-nutrition/article4137315/  A fost proiectata ideea ca ridicarea pe tot parcursul anului a nivelurilor serice minime de vitamina D, de la 20 ng/ml pana la 40-60 ng/ml ar putea preveni aparitia a aproximativ 58000 de cazuri noi de cancer de san si a 49000 de cazuri noi de cancer colorectal in fiecare an.
Ann Epidemiol. 2009 Jul;19(7):468-83. doi: 10.1016/j.annepidem.2009.03.021. Vitamin D for cancer prevention: global perspective. Garland CF1, Gorham ED, Mohr SB, Garland FC.  Rezultatele arata ca apararea antioxidanta a organismului este semnificativ scazuta in caz de osteoporoza.
J Clin Endocrinol Metab. 2003 Apr;88(4):1523-7. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. Maggio D1, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, Senin U, Pacifici R, Cherubini A.  Pe langa rolul sau ca si antioxidant, se pare ca vitamina E are mai multe modalitati de actiune care vor duce la efecte antiaterogene (anti-ateroscleroza).
Free Radic Biol Med. 2000 Oct 15;29(8):790-2. Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. Devaraj S1, Jialal I. |
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Août 2017
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