In most cases, ovarian cancer is detected at an advanced clinical stage and the results gives a poor prognostic. Surgical debulking and chemotherapy (cisplastin and oxiplatin) are the first line interventions.
Unfortunately, many patients experience recurrence and metastasis due to incomplete surgery and resistance of neoplastic cells to chemotherapy. Medicinal plants and nutraceuticals are containing flavones, flavonoids, vitamins, minerals and antioxidants. Resveratrol inhibits the growth of ovarian carcinoma cells in vitro through the inhibition of glucose metabolism and the induction of both autophagy and apoptosis. Hipercholesterolemia prevention can be achieved by lifestyle changes, a diet rich in vitamins and low in saturated fat and nutraceutical compounds. Hypercholesterolemic people require a higher amount of antioxidants to reduce the oxidation level. Today, more than 40 orthomolecular substances have been tested and proven to aid peoples suffering from hypercholesterolemia. One of these substances is vitamin C. In most of hypercholesterolemic persons with a low vitamin C status, the administration of ascorbic acid in doses 500-1000 mg per day lowers total cholesterol concentration in blood plasma. REFERENCE:
Int J Vitam Nutr Res Suppl. 1982;23:137-52. Vitamin C in the control of hypercholesterolemia in man. Ginter E, Bobek P, Kubec F, Vozár J, Urbanová D. An increasing amount of evidence shows that oxygen derived free radicals are able to cause damage to membranes, mitochondria, and macromolecules including proteins, lipids and DNA. Accumulation of all these damages can contribute to carcinogenesis. A high proportion of cancer incidence and death are due to different factors such as high body mass index, low fruit and vegetable intake, lack of physical activity, tobacco use, alcohol consumption, exposure to radiation, chronic infections and heredity also. The ω-3 PUFA, docosahexaenoic acid (DHA), shows anticancer activity by inducing apoptosis of some human cancer cells without toxicity against normal cells. DHA shows a variable inhibitory effect on cancer cell growth depending on the cells' molecular properties and degree of malignancy. REFERENCE:
Int J Mol Sci. 2016 Aug 3;17(8). pii: E1257. doi: 10.3390/ijms17081257. Docosahexaenoic Acid Induces Oxidative DNA Damage and Apoptosis, and Enhances the Chemosensitivity of Cancer Cells. Song EA1, Kim H2. Periodontal disease is a progressive, inflammatory disease affecting tooth supporting tissues. It is associated with oral bacterial dysbiosis, dysregulation of immune response (chronic inflammation), oxidative stress, periodontium destruction and tooth loss. Oxidative stress is defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defences. Patients with periodontal disease seems to have a high level of oxidative stress produces by a large number of free radicals (toxins) and a reduced antioxidant capacity. Ascorbic acid deficiency has been shown to be a conditioning factor in the development of gingivitis. When humans are placed on ascorbic acid deficient diets there is increased edema, redness and swelling of the gingiva. These changes have been attributed to deficient collagen production by gingival blood vessels. REFERENCE:
J Theor Biol. 1984 May 21;108(2):163-71. The role of ascorbic acid deficiency in human gingivitis--a new hypothesis. Nakamoto T, McCroskey M, Mallek HM. https://www.ncbi.nlm.nih.gov/pubmed/6748685 We cannot live without cholesterol. Cholesterol is a natural component of all the cells in the body and is essential in the production of the sex hormones and vitamin D metabolism. The cholesterol in our body has 2 origins: the endogenous source - the liver is the main place where the cholesterol is synthetized and the exogenous source coming from the diet. There are two types of cholesterol, HDL (high density lipoproteins, or "good" cholesterol) and LDL (low density lipoproteins, or "bad" cholesterol). The LDL (bad) cholesterol is picking up the cholesterol molecules from the liver and deliver it to cells. HDL (good) cholesterol remove excess cholesterol from the blood and take it to the liver. Study conclude that, the combined administration of atorvastatin and CoQ10 improved biochemical parameters, liver function and mitochondrial respiration in hypercholesterolemic rats. This beneficial effect of CoQ10 must be combined with statin treatment in patient with high levels of cholesterol. REFERENCE:
Lipids Health Dis. 2014 Jan 25;13:22. doi: 10.1186/1476-511X-13-22. Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet. Jiménez-Santos MA1, Juárez-Rojop IE, Tovilla-Zárate CA, Espinosa-García MT, Juárez-Oropeza MA, Ramón-Frías T, Bermúdez-Ocaña DY, Díaz-Zagoya JC. The use of Complementary & Alternative Medical (CAM) therapies as adjunctive therapies will continue to grow and the patients deserve the willingness to use all possible approaches to improving their outcomes. Therefore, there is an urgent need to develop non-toxic, science-based approaches for the management of cancer. Integrative oncology represents a holistic approach to patient care whose goal is maximization of patient quantity and quality of life through the synergy of conventional care, integrative modalities, lifestyle modifications (stress management, diet, supplementation) and supportive care. Colon cancer incidence rates also have been shown to be inversely proportional to intake of calcium. These findings, which are consistent with laboratory results, indicate that most cases of colon cancer may be prevented with regular intake of calcium in the range of 1,800 mg per day, in a dietary context that includes 800 IU per day (20 micrograms) of vitamin D3. If you want to read the original article:
https://www.ncbi.nlm.nih.gov/pubmed/10668487 Ann N Y Acad Sci. 1999;889:107-19. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Garland CF1, Garland FC, Gorham ED. Increased free radical production overwhelms the natural antioxidants defense mechanisms, subjecting individuals to hyperoxidant stress and thus leading to osteoporosis. The results reveal that antioxidant defenses are markedly decreased in osteoporotic women and male patients. Therefore, it may be suggested that oxidative stress plays an important role in the pathophysiology of osteoporosis is associated with increased bone resorption and low bone mass in otherwise healthy women. The total mineral and vitamin intake required for bone health (calcium, magnesium, phosphorus & vitamin D) was below the recommended, among majority of the sample. REFERENCE:
Pak J Med Sci. 2015 Jul-Aug;31(4):970-4. doi: 10.12669/pjms.314.8433. Bone mineral density and diet of teachers of College of Home Economics at Lahore. Javed Z1, Imam SF2, Imam N3, Saba K4, Bukhari MH5. Deficiencies of several B vitamins have been associated with cognitive dysfunction in many observational studies. More recently, deficiencies of folate (B9) and cobalamine (B12) have been studied in relation to hyperhomocysteinemia as potential determinants of cognitive impairment, dementia, and Alzheimer's disease. REFERENCE:
Brain Res Bull. 2006 Mar 15;69(1):1-19. Epub 2005 Nov 21. Nutritional factors, cognitive decline, and dementia.Del Parigi A1, Panza F, Capurso C, Solfrizzi V. Author information Abstract Nutritional factors and nutritional deficiencies have been repeatedly associated with cognitive impairment. Most of the evidence is based on cross-sectional studies, which cannot prove whether a nutritional deficit is the cause or the consequence of an impaired cognitive status. In fact, cognitive impairment, in turn, can determine changes in dietary habits and consequent nutritional deficiencies. We reviewed clinical and epidemiological studies from January 1983 to June 2004. Several cross-sectional and fewer prospective studies reported an association between dietary or supplemental intake of antioxidants and protection from cognitive decline and dementia. There are negative reports as well and some methodological biases might have affected the consistencies across studies. Deficiencies of several B vitamins have been associated with cognitive dysfunction in many observational studies. More recently, deficiencies of folate (B9) and cobalamine (B12) have been studied in relation to hyperhomocysteinemia as potential determinants of cognitive impairment, dementia, and Alzheimer's disease (AD). A small number of studies assessed the association between intake of macronutrients and cognitive function or dementia. Among the others, the intake of fatty acids and cholesterol has received particular attention. Although the results are not always consistent, most studies have reported a protective role of dietary intakes of poly- and mono-unsaturated fatty acids against cognitive decline and AD. We point out that well designed intervention studies are warranted in order to establish specific levels of micro- and macronutrient deficiencies and to set general recommendations for the population. The results demonstrated that 1,25(OH)2D3 deficiency could induce colon inflammation, which may result from increased oxidative stress and DNA damage, subsequently, induced cell senescence and overproduction of senescence-associated secretory factors. 1,25(OH)2D3 may play an important role in preventing the development and progression of colon inflammation and colon cancer. Abstract
Epidemiological studies showed that 1,25-Dihydroxyvitamin D[1,25(OH)2D3] insufficiency appears to be associated with aging and colon cancer while underlying biological mechanisms remain largely unknown. Inflammatory bowel disease is one of the risk factors for colon cancer. In this study, we investigated whether 1,25(OH)2D3 deficiency has an impact on the colon of 25-hydroxyvitamin D 1α-hydroxylase knockout [Cyp27b1(-/-)] mice fed on a rescue diet (high calcium, phosphate, and lactose) from weaning to 10 months of age. We found that 1,25(OH)2D3 deficient mice displayed significant colon inflammation phenotypes including shortened colon length, thinned and disordered mucosal structure, and inflammatory cell infiltration. DNA damage, cellular senescence and the production of senescence-associated inflammatory cytokines were also increased significantly in the colon of Cyp27b1(-/-)mice. Furthermore, the levels of ROS in the colon were increased significantly, whereas the expression levels of antioxidative genes were down-regulated dramatically in the colon of Cyp27b1(-/-)mice. Taken together, our results demonstrated that 1,25(OH)2D3 deficiency could induce colon inflammation, which may result from increased oxidative stress and DNA damage, subsequently, induced cell senescence and overproduction of senescence-associated secretory factors. Therefore, our findings suggest that 1,25(OH)2D3 may play an important role in preventing the development and progression of colon inflammation and colon cancer. REFERENCE: PLoS One. 2016 Jan 20;11(1):e0146426. doi: 10.1371/journal.pone.0146426. eCollection 2016. 1,25(OH)2D3 Deficiency Induces Colon Inflammation via Secretion of Senescence-Associated Inflammatory Cytokines. Liu Y1, Chen L1, Zhi C1, Shen M2, Sun W1, Miao D1, Yuan X1. By Richard Drucker, PhD
http://www.nutritionalwellness.com/archives/2006/jul/07_depleted_soil.php
Inorganic (synthetic/dead), ammonium-based fertilizers, along with herbicides and pesticides, kill the precious microorganisms in the soil that are essential to the creation of organic (carbon-based/living) mineral complexes. We have done more than simply use up the available trace minerals in our soils (those in the form of organic complexes). WE ALSO HAVE DESTROYED THE MEANS OF REPLENISHING THESE SOIL-BASED MICROORGANISMS. It is also easy to understand what Linus Pauling (twice awarded the Nobel Prize in medicine) meant when he explained to the 74th Congress of the United Sates, "Every ailment, every sickness and every disease can be traced back to an organic trace mineral deficiency." 17. SOIL MINERAL DEPLETION - CAN A HEALTHY DIET BE SUFFICIENT IN TODAY'S WORLD ? 18. SOIL DEPLETION |
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